Simple jQuery Dropdowns
Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/12534
Title: Coronary-artery bypass surgery in patients with left ventricular dysfunction
Authors: Eric J. Velazquez
Kerry L. Lee
Marek A. Deja
Anil Jain
George Sopko
Andrey Marchenko
Imtiaz S. Ali
Gerald Pohost
Sinisa Gradinac
William T. Abraham
Michael Yii
Dorairaj Prabhakaran
Hanna Szwed
Paolo Ferrazzi
Mark C. Petrie
Christopher M. O'Connor
Pradit Panchavinnin
Lilin She
Robert O. Bonow
Gena Roush Rankin
Robert H. Jones
Jean Lucien Rouleau
Duke University School of Medicine
Duke Clinical Research Institute
Slaski Uniwersytet Medyczny w Katowicach
Instytut Kardiologii im. Prymasa Tysiaclecia Stefana Kardynala Wyszynskiego
SAL Hospital and Medical Institute
Center for Chronic Disease Control
National Heart, Lung, and Blood Institute
Novosibirsk Research Institute of Circulation Pathology Academician EN Meshalkina (NNIIPK)
Dalhousie University
Keck School of Medicine of USC
University of Belgrade
Ohio State University
University of Melbourne
Ospedali Riuniti Di Bergamo
Golden Jubilee National Hospital
Mahidol University
Northwestern University
Institut de Cardiologie de Montreal
Keywords: Medicine
Issue Date: 28-Apr-2011
Citation: New England Journal of Medicine. Vol.364, No.17 (2011), 1607-1616
Abstract: BACKGROUND: The role of coronary-artery bypass grafting (CABG) in the treatment of patients with coronary artery disease and heart failure has not been clearly established. METHODS: Between July 2002 and May 2007, a total of 1212 patients with an ejection fraction of 35% or less and coronary artery disease amenable to CABG were randomly assigned to medical therapy alone (602 patients) or medical therapy plus CABG (610 patients). The primary outcome was the rate of death from any cause. Major secondary outcomes included the rates of death from cardiovascular causes and of death from any cause or hospitalization for cardiovascular causes. RESULTS: The primary outcome occurred in 244 patients (41%) in the medical-therapy group and 218 (36%) in the CABG group (hazard ratio with CABG, 0.86; 95% confidence interval [CI], 0.72 to 1.04; P = 0.12). A total of 201 patients (33%) in the medical-therapy group and 168 (28%) in the CABG group died from an adjudicated cardiovascular cause (hazard ratio with CABG, 0.81; 95% CI, 0.66 to 1.00; P = 0.05). Death from any cause or hospitalization for cardiovascular causes occurred in 411 patients (68%) in the medical-therapy group and 351 (58%) in the CABG group (hazard ratio with CABG, 0.74; 95% CI, 0.64 to 0.85; P < 0.001). By the end of the follow-up period (median, 56 months), 100 patients in the medical-therapy group (17%) underwent CABG, and 555 patients in the CABG group (91%) underwent CABG. CONCLUSIONS: In this randomized trial, there was no significant difference between medical therapy alone and medical therapy plus CABG with respect to the primary end point of death from any cause. Patients assigned to CABG, as compared with those assigned to medical therapy alone, had lower rates of death from cardiovascular causes and of death from any cause or hospitalization for cardiovascular causes. (Funded by the National Heart, Lung, and Blood Institute and Abbott Laboratories; STICH ClinicalTrials.gov number, NCT00023595.) Copyright © 2011 Massachusetts Medical Society.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=79955494359&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/12534
ISSN: 15334406
00284793
Appears in Collections:Scopus 2011-2015

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.