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Title: Enzyme-linked immunosorbent assay for the diagnosis of melioidosis: Better than we thought
Authors: Direk Limmathurotsakul
Narisara Chantratita
Nittaya Teerawattanasook
Komson Piriyagitpaiboon
Aunchalee Thanwisai
Vanaporn Wuthiekanun
Nicholas P J Day
Ben Cooper
Sharon J. Peacock
Mahidol University
Department of Clinical Pathology
Sappasitthiprasong Hospital
Nuffield Department of Clinical Medicine
University of Cambridge
Keywords: Medicine
Issue Date: 15-Apr-2011
Citation: Clinical Infectious Diseases. Vol.52, No.8 (2011), 1024-1028
Abstract: We used Bayesian latent-class models to generate receiver operating characteristic curves and to revise the cutoff values for an enzyme-linked immosorbent assay that has been developed previously for melioidosis. The new cutoff was unbiased towards misclassification caused by an imperfect gold standard and resulted in an increase in both sensitivity (from 66.4% to 80.2%) and specificity (82.1% and 95.0%). © 2011 The Author.
ISSN: 15376591
Appears in Collections:Scopus 2011-2015

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