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Title: Effects of anticholinergic drugs on cognitive function in older Australians: Results from the AIBL study
Authors: Gobhathai Sittironnarit
David Ames
Ashley I. Bush
Noel Faux
Leon Flicker
Jonathan Foster
Sarah Hilmer
Nicola T. Lautenschlager
Paul Maruff
Colin L. Masters
Ralph N. Martins
Christopher Rowe
Cassandra Szoeke
Kathryn A. Ellis
Mahidol University
National Ageing Research Institute
Mental Health Research Institute of Victoria
Department of Pathology
University of Melbourne
CogState Ltd.
Austin Health
Commonwealth Scientific and Industrial Research Organization
Western Australian Centre for Health and Ageing
University of Western Australia
Hollywood Private Hospital
Edith Cowan University, Joondalup
The University of Sydney
Keywords: Medicine;Neuroscience
Issue Date: 1-Apr-2011
Citation: Dementia and Geriatric Cognitive Disorders. Vol.31, No.3 (2011), 173-178
Abstract: Background/Aims: The nature and extent of adverse cognitive effects due to the prescription of anticholinergic drugs in older people with and without dementia is unclear. Methods: We calculated the anticholinergic load (ACL) of medications taken by participants of the Australian Imaging, Biomarkers and Lifestyle (AIBL) study of ageing, a cohort of 211 Alzheimer's disease (AD) patients, 133 mild cognitive impairment (MCI) patients and 768 healthy controls (HC) all aged over 60 years. The association between ACL and cognitive function was examined for each diagnostic group (HC, MCI, AD). Results: A high ACL within the HC group was associated with significantly slower response speeds for the Stroop color and incongruent trials. No other significant relationships between ACL and cognition were noted. Conclusion: In this large cohort, prescribed anticholinergic drugs appeared to have modest effects upon psychomotor speed and executive function, but not on other areas of cognition in healthy older adults. Copyright © 2011 S. Karger AG, Basel.
ISSN: 14208008
Appears in Collections:Scopus 2011-2015

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