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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/12592
Title: Effectiveness of deferiprone in transfusionindependent beta-thalassemia/HbE patients
Authors: Krittapoom Akrawinthawong
Nithima Chaowalit
Thanasaporn Chatuparisuth
Noppadol Siritanaratkul
Mahidol University
Keywords: Medicine
Issue Date: 1-Mar-2011
Citation: Hematology. Vol.16, No.2 (2011), 113-122
Abstract: Beta-thalassemia/HbE (beta-thal/HbE) is a thalassemia intermedia (TI) which encompasses a broad spectrum of severity. Here, we used deferiprone (DFP) as an iron chelating agent in TI patients receiving intermittent blood transfusion who are asymptomatic for cardiovascular disease in order to evaluate the effectiveness in iron overload and reduce the possibility of cardiovascular complications. Thirty transfusionin-dependent beta-thal/HbE patients with iron overload were treated with DFP for 1 year. Hematological, biochemical, oxidative stress and echocardiographic parameters were determined. Serum ferritin, nontransferrin-bound iron, and malondialdehyde decreased significantly (P < 0.05) after 1-year treatment with DFP. For echocardiographic results, mean pulmonary arterial pressure and pulmonary vascular resistance were diminished significantly (P < 0.05). All those parameters were still improved after subgroup analysis was done for the high ferritin group ( > 2500 ng/ml). DFP therapy alone improved iron overload and oxidative stress and compliance was good. We propose that prevention of pulmonary hypertension is also possible for TI undergoing intermittent blood transfusion. © W. S. Maney & Son Ltd 2011.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=79952658675&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/12592
ISSN: 16078454
10245332
Appears in Collections:Scopus 2011-2015

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