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Title: Early gastric cancer: The first case series in Thailand
Authors: Asada Methasate
Atthaphorn Trakarnsanga
Thawatchai Akaraviputh
Vitoon Chinsawangwathanako
Darin Lohsiriwat
Mahidol University
Keywords: Medicine
Issue Date: 1-Mar-2011
Citation: Journal of the Medical Association of Thailand. Vol.94, No.3 (2011), 316-322
Abstract: Background: Early gastric cancer (EGC) defined as gastric cancer involving up to submucosal layer, regardless of lymph node metastasis, is increasingly found at Siriraj Hospital. Understanding the characteristic of EGC and result of surgical management for EGC can help to choose the optimal treatment. In the present study, the authors reported the first case series in Thailand. Material and Method: The authors analyzed 21 consecutive EGC patients treated with gastrectomy with lymph node dissection between September 2001 and December 2009 at Minimally Invasive Surgery Center, Division of General Surgery, Department of Surgery, Siriraj Hospital, Mahidol University, Thailand. Results: Ratio of EGC to total cases of gastric cancer was increasing yearly, from 1.8% in 2006 to 8.1% in 2009 at Siriraj Hospital. The most common type of EGC was type IIc (66.7%) while type III was found in 19%, and type I in 14.3%. The tumor invaded mucosal layer in 42.9% and submucosal layer in 57.1% of the patients. For N staging, 76.2% of the patients were N0 while N1 was 19% and N2 was 4.8%. Overall, lymph node metastasis was found in 23.8%. For mucosal cancer (m), no lymph node metastasis was seen while for submucosal cancer (sm) five cases (41.7%) had lymph node metastasis, especially in one patient that the metastasis was in N2 group. Lymphatic invasion was seen in 14.3% of cases. All cases with lymphatic invasion were all submucosal cancer. Overall staging was stage 1a in 76.2%, stage 1b in 19%, and stage 2 in 4.8%. Morbidity was seen in 14.3% of the cases. No mortality was seen. The survival was excellent with no recurrence found during the follow-up period of the present study (mean 30.53 months). Conclusion: Surgery for EGC has good results with minimal complications and excellent 5-year survival. Less invasive treatment has become the option for EGC. Understanding the characteristic of EGC and careful selection to assign appropriate treatment is important to improve the result in the treatment of EGC.
ISSN: 01252208
Appears in Collections:Scopus 2011-2015

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