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Title: Comparisons of methamphetamine psychotic and schizophrenic symptoms: A differential item functioning analysis
Authors: Manit Srisurapanont
Suwanna Arunpongpaisal
Kiyoshi Wada
John Marsden
Robert Ali
Ronnachai Kongsakon
Chiang Mai University
Khon Kaen University
National Institute of Mental Health
King's College London
University of Adelaide
Mahidol University
Keywords: Neuroscience;Pharmacology, Toxicology and Pharmaceutics
Issue Date: 1-Jun-2011
Citation: Progress in Neuro-Psychopharmacology and Biological Psychiatry. Vol.35, No.4 (2011), 959-964
Abstract: The concept of negative symptoms in methamphetamine (MA) psychosis (e.g., poverty of speech, flatten affect, and loss of drive) is still uncertain. This study aimed to use differential item functioning (DIF) statistical techniques to differentiate the severity of psychotic symptoms between MA psychotic and schizophrenic patients. Data of MA psychotic and schizophrenic patients were those of the participants in the WHO Multi-Site Project on Methamphetamine-Induced Psychosis (or WHO-MAIP study) and the Risperidone Long-Acting Injection in Thai Schizophrenic Patients (or RLAI-Thai study), respectively. To confirm the unidimensionality of psychotic syndromes, we applied the exploratory and confirmatory factor analyses (EFA and CFA) on the eight items of Manchester scale. We conducted the DIF analysis of psychotic symptoms observed in both groups by using nonparametric kernel-smoothing techniques of item response theory. A DIF composite index of 0.30 or greater indicated the difference of symptom severity. The analyses included the data of 168 MA psychotic participants and the baseline data of 169 schizophrenic patients. For both data sets, the EFA and CFA suggested a three-factor model of the psychotic symptoms, including negative syndrome (poverty of speech, psychomotor retardation and flatten/incongruous affect), positive syndrome (delusions, hallucinations and incoherent speech) and anxiety/depression syndrome (anxiety and depression). The DIF composite indexes comparing the severity differences of all eight psychotic symptoms were lower than 0.3. The results suggest that, at the same level of syndrome severity (i.e., negative, positive, and anxiety/depression syndromes), the severity of psychotic symptoms, including the negative ones, observed in MA psychotic and schizophrenic patients are almost the same. © 2011 Elsevier Inc.
ISSN: 18784216
Appears in Collections:Scopus 2011-2015

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