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Title: Curcumin I protects the dopaminergic cell line SH-SY5Y from 6-hydroxydopamine-induced neurotoxicity through attenuation of p53-mediated apoptosis
Authors: Yamaratee Jaisin
Anusorn Thampithak
Benjawan Meesarapee
Piyanee Ratanachamnong
Apichart Suksamrarn
Laddawal Phivthong-ngam
Noppawan Phumala-Morales
Sukumal Chongthammakun
Piyarat Govitrapong
Yupin Sanvarinda
Mahidol University
Burapha University
Ramkhamhaeng University
Srinakharinwirot University
Keywords: Neuroscience
Issue Date: 11-Feb-2011
Citation: Neuroscience Letters. Vol.489, No.3 (2011), 192-196
Abstract: Oxidative stress (OS) plays a pivotal role in the pathogenesis of Parkinson's disease (PD). 6-Hydroxydopamine (6-OHDA) is a neurotoxin used to induce oxidative cell death of dopaminergic neurons in experimental models of PD. Curcumin I, or diferuloylmethane is a pure compound isolated from Curcuma longa Linn. that has been reported to have neuroprotective properties. The precise mechanism, however, remains unclear. This study aims to elucidate the mechanisms by which curcumin I exerts its effects, using 6-OHDA-induced neurotoxicity in the human dopaminergic cell line SH-SY5Y. In our experiments, pretreatment with curcumin I improved cell viability, and significantly reduced reactive oxygen species (ROS). Further investigations revealed a reduction of p53 phosphorylation and decrease of the Bax/Bcl-2 ratio, as measured by mRNA expression and protein level. Taken together, these findings indicate that curcumin I protects dopaminergic neurons from 6-OHDA-induced toxicity via the reduction of ROS production, and subsequent attenuation of p53 phosphorylation and reduction of the Bax/Bcl-2 ratio. © 2010 Elsevier Ireland Ltd.
ISSN: 03043940
Appears in Collections:Scopus 2011-2015

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