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dc.contributor.authorYamaratee Jaisinen_US
dc.contributor.authorAnusorn Thampithaken_US
dc.contributor.authorBenjawan Meesarapeeen_US
dc.contributor.authorPiyanee Ratanachamnongen_US
dc.contributor.authorApichart Suksamrarnen_US
dc.contributor.authorLaddawal Phivthong-ngamen_US
dc.contributor.authorNoppawan Phumala-Moralesen_US
dc.contributor.authorSukumal Chongthammakunen_US
dc.contributor.authorPiyarat Govitrapongen_US
dc.contributor.authorYupin Sanvarindaen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherBurapha Universityen_US
dc.contributor.otherRamkhamhaeng Universityen_US
dc.contributor.otherSrinakharinwirot Universityen_US
dc.date.accessioned2018-05-03T08:40:08Z-
dc.date.available2018-05-03T08:40:08Z-
dc.date.issued2011-02-11en_US
dc.identifier.citationNeuroscience Letters. Vol.489, No.3 (2011), 192-196en_US
dc.identifier.issn03043940en_US
dc.identifier.other2-s2.0-78751575381en_US
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=78751575381&origin=inwarden_US
dc.identifier.urihttp://repository.li.mahidol.ac.th/dspace/handle/123456789/12790-
dc.description.abstractOxidative stress (OS) plays a pivotal role in the pathogenesis of Parkinson's disease (PD). 6-Hydroxydopamine (6-OHDA) is a neurotoxin used to induce oxidative cell death of dopaminergic neurons in experimental models of PD. Curcumin I, or diferuloylmethane is a pure compound isolated from Curcuma longa Linn. that has been reported to have neuroprotective properties. The precise mechanism, however, remains unclear. This study aims to elucidate the mechanisms by which curcumin I exerts its effects, using 6-OHDA-induced neurotoxicity in the human dopaminergic cell line SH-SY5Y. In our experiments, pretreatment with curcumin I improved cell viability, and significantly reduced reactive oxygen species (ROS). Further investigations revealed a reduction of p53 phosphorylation and decrease of the Bax/Bcl-2 ratio, as measured by mRNA expression and protein level. Taken together, these findings indicate that curcumin I protects dopaminergic neurons from 6-OHDA-induced toxicity via the reduction of ROS production, and subsequent attenuation of p53 phosphorylation and reduction of the Bax/Bcl-2 ratio. © 2010 Elsevier Ireland Ltd.en_US
dc.rightsMahidol Universityen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=78751575381&origin=inwarden_US
dc.subjectNeuroscienceen_US
dc.titleCurcumin I protects the dopaminergic cell line SH-SY5Y from 6-hydroxydopamine-induced neurotoxicity through attenuation of p53-mediated apoptosisen_US
dc.typeArticleen_US
dc.rights.holderSCOPUSen_US
dc.identifier.doi10.1016/j.neulet.2010.12.014en_US
Appears in Collections:Scopus 2011-2015

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