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Title: Cytotoxic alkaloids from stems, leaves and twigs of Dasymaschalon blumei
Authors: Waraporn Chanakul
Patoomratana Tuchinda
Natthinee Anantachoke
Manat Pohmakotr
Pawinee Piyachaturawat
Surawat Jariyawat
Kanoknetr Suksen
Tharworn Jaipetch
Narong Nuntasaen
Vichai Reutrakul
Mahidol University
National Park, Wildlife and Plant Conservation Department, Thailand
Keywords: Pharmacology, Toxicology and Pharmaceutics
Issue Date: 1-Oct-2011
Citation: Fitoterapia. Vol.82, No.7 (2011), 964-968
Abstract: Bioassay-guided fractionation of the cytotoxic ethyl acetate extract from the stems of Dasymaschalon blumei (Annonaceae) led to the isolation of four aristololactam alkaloids, including the hitherto unknown 3,5-dihydroxy-2,4- dimethoxyaristolactam (1), as well as the three known compounds, aristolactam BI, goniopedaline, and griffithinam. Additionally, the cytotoxic extract from the combined leaves and twigs of the same plant yielded three known oxoaporphine alkaloids, oxodiscoguattine, dicentrinone, and duguevalline. The structures of aristolactams and oxoaporphine alkaloids were elucidated on the basis of spectroscopic methods. All isolates were evaluated for cytotoxicity against a panel of mammalian cancer cell lines and a noncancerous human embryonic kidney cell Hek 293. © 2011 Elsevier B.V.
ISSN: 18736971
Appears in Collections:Scopus 2011-2015

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