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Title: Development of acyclovir-loaded bovine serum albumin nanoparticles for ocular drug delivery
Authors: Pawinee Noomwong
Wantanee Ratanasak
Assadang Polnok
Narong Sarisuta
Mahidol University
Naresuan University
Keywords: Pharmacology, Toxicology and Pharmaceutics
Issue Date: 1-Jan-2011
Citation: International Journal of Drug Delivery. Vol.3, No.4 (2011), 669-675
Abstract: The aim of the present study was to develop acyclovir (ACV) ocular drug delivery systems of bovine serum albumin (BSA) nanoparticles as well as to assess their in vivo transcorneal permeability. The ACV-loaded nanoparticles with 4% and 8% drug loading were prepared by desolvation method. Morphology of the nanoparticles under scanning electron microscopy was spherical in shape and uniform in size. The mean sizes and entrapment efficiencies of ACV-loaded BSA nanoparticles were in the range of 125 - 132 nm and 15 - 25%, respectively. Increasing the amount of ACV added into the formulation led to significant reduction of entrapment efficiency of nanoparticles. The results from in vivo transcorneal permeation studies revealed that ACV-loaded BSA nanoparticles could readily permeate through the rabbits' cornea and bring about maximum ACV concentrations within 30 min and prolonged till 120 min.
ISSN: 09754415
Appears in Collections:Scopus 2011-2015

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