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Title: Avenolide, a Streptomyces hormone controlling antibiotic production in Streptomyces avermitilis
Authors: Shigeru Kitani
Kiyoko T. Miyamoto
Satoshi Takamatsu
Elisa Herawati
Hiroyuki Iguchi
Kouhei Nishitomi
Miho Uchida
Tohru Nagamitsu
Satoshi Omura
Haruo Ikeda
Takuya Nihira
Osaka University
Kitasato University
Mahidol University
Keywords: Multidisciplinary
Issue Date: 27-Sep-2011
Citation: Proceedings of the National Academy of Sciences of the United States of America. Vol.108, No.39 (2011), 16410-16415
Abstract: Gram-positive bacteria of the genus Streptomyces are industrially important microorganisms, producing > 70% of commercially important antibiotics. The production of these compounds is often regulated by low-molecular-weight bacterial hormones called autoregulators. Although 60% of Streptomyces strains may use γ-butyrolactone-type molecules as autoregulators and some use furan- type molecules, little is known about the signaling molecules used to regulate antibiotic production in many other members of this genus. Here, we purified a signaling molecule (avenolide) from Streptomyces avermitilis - the producer of the important anthelmintic agent avermectin with annual world sales of $850 million - and determined its structure, including stereochemistry, by spectroscopic analysis and chemical synthesis as (4S,10R)-10-hydroxy-10- methyl-9-oxo-dodec-2-en-1,4-olide, a class of Streptomyces autoregulator. Avenolide is essential for eliciting avermectin production and is effective at nanomolar concentrations with a minimum effective concentration of 4 nM. The aco gene of S. avermitilis, which encodes an acyl-CoA oxidase, is required for avenolide biosynthesis, and homologs are also present in Streptomyces fradiae, Streptomyces ghanaensis, and Streptomyces griseoauranticus, suggesting that butenolide-type autoregulators may represent a widespread and another class of Streptomyces autoregulator involved in regulating antibiotic production.
ISSN: 10916490
Appears in Collections:Scopus 2011-2015

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