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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/12917
Title: Canopy1, a positive feedback regulator of FGF signaling, controls progenitor cell clustering during Kupffer's vesicle organogenesis
Authors: Takaaki Matsui
Siripong Thitamadee
Tomoko Murata
Hisaya Kakinuma
Takuji Nabetani
Yoshio Hirabayashi
Yoshikazu Hirate
Hitoshi Okamotob
Yasumasa Bessho
Nara Institute of Science and Technology
Brain Science Institute Wako
Kumamoto University
Mahidol University
Keywords: Multidisciplinary
Issue Date: 14-Jun-2011
Citation: Proceedings of the National Academy of Sciences of the United States of America. Vol.108, No.24 (2011), 9881-9886
Abstract: The assembly of progenitor cells is a crucial step for organ formation during vertebrate development. Kupffer's vesicle (KV), a key organ required for the left-right asymmetric body plan in zebrafish, is generated from a cluster of ∼20 dorsal forerunner cells (DFCs). Although several genes are known to be involved in KV formation, how DFC clustering is regulated and how cluster formation then contributes to KV formation remain unclear. Here we show that positive feedback regulation of FGF signaling by Canopy1 (Cnpy1) controls DFC clustering. Cnpy1 positively regulates FGF signals within DFCs, which in turn promote Cadherin1-mediated cell adhesion between adjacent DFCs to sustain cell cluster formation. When this FGF positive feedback loop is disrupted, the DFC cluster fails to form, eventually leading to KV malformation and defects in the establishment of laterality. Our results therefore uncover both a previously unidentified role of FGF signaling during vertebrate organogenesis and a regulatory mechanism underlying cell cluster formation, which is an indispensable step for formation of a functional KV and establishment of the left-right asymmetric body plan.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=79959942551&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/12917
ISSN: 10916490
00278424
Appears in Collections:Scopus 2011-2015

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