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Title: Modification of relative potencies of beta-adrenoceptor agonists by negative chronotropic agents in rat atrium
Authors: C. Sadavongvivad
J. Satayavivad
V. Prachayasittikul
L. Mo-Suwun
Mahidol University
Keywords: Pharmacology, Toxicology and Pharmaceutics
Issue Date: 1-Dec-1978
Citation: General Pharmacology: Vascular System. Vol.8, No.4 (1978), 263-267
Abstract: Lowering temperature r420w9 =and the reduced maximal effects of all four common adrenoceptor agonists without any change in their potencies. Quinidine reduced their potencies slightly and lowered maximal effects only at high concentrations. Adenosine caused a large decrease in potency of isoprenaline but hardly affected that of phenylephrine. These andthe authors previous results indicate that some endogeneous negative chronotropic agents can alter relative potencies of the agonists as well as characteristics of blockers.
ISSN: 03063623
Appears in Collections:Scopus 1969-1990

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