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Title: Chronic Ingestion of High Dosed Phikud Navakot Extraction Induces Mesangiolysis in Rats with Alteration of AQP1 and Hsp60 Expressions
Authors: Kanchana Kengkoom
Sumate Ampawong
Mahidol University. National Laboratory Animal Centre
Mahidol University. Faculty of Tropical Medicine
Keywords: AQP1;Hsp60;Mesangiolysis;Phikud Navakot;Oral chronic toxicity;Sprague Dawley rat;Open Access article
Issue Date: 10-Feb-2015
Citation: BioMed Research International. Vol. 2015. Article ID 462387
Abstract: Phikud Navakot (PN) is commonly used in Thai traditional medicine for alleviation 18 of cardiovascular and cerebrovascular symptoms, however little is known about the 19 chronic toxicity effects of the extracts from the herbs in PN. Repeated extraction doses of 20 10, 100, and 1,000 mg/kg/day were randomly administered to both male and female 21 Sprague Dawley rats for 12 months. Histopathological study revealed that mesangiolysis 22 was predominately found at the highest dose. Aquaporin 1 (AQP1) expression in the 23 mesangiolytic glomeruli was significantly lower than in the intact glomeruli. This may 24 relevant to an imbalance of vascular function manifested by AQP1 alteration. In the 25 mesangiolytic glomeruli, 60 kDa heat shock protein (Hsp60) was significantly up- 26 regulated on the endothelial lining cells of aneurysm and vascular cyst. Hsp60 increase 27 may be related to endothelial cell damage due to its intracellular protective role. Blood 28 urea nitrogen and creatinine levels were remained within their normal range indicating 29 well-functioning renal reserve function. In conclusion, high dosed PN may affect the 30 endothelium leading to inability of vascular permeability and consequence to 31 mesangiolysis. Our results suggest that only a high dose of chronic oral administration of 32 PN is relatively toxic in association with mesangiolysis. The NOAEL was determined to 33 be 100 mg/kg/day
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