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dc.contributor.authorKristina B. Clarken_US
dc.contributor.authorSansanee Noisakranen_US
dc.contributor.authorNattawat Onlamoonen_US
dc.contributor.authorHui Mien Hsiaoen_US
dc.contributor.authorJohn Robacken_US
dc.contributor.authorFrancois Villingeren_US
dc.contributor.authorAftab A. Ansarien_US
dc.contributor.authorGuey Chuen Perngen_US
dc.contributor.otherEmory University School of Medicineen_US
dc.contributor.otherThailand National Center for Genetic Engineering and Biotechnologyen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherEmory Universityen_US
dc.contributor.otherNational Cheng Kung Universityen_US
dc.date.accessioned2018-06-11T04:29:07Z-
dc.date.available2018-06-11T04:29:07Z-
dc.date.issued2012-12-27en_US
dc.identifier.citationPLoS ONE. Vol.7, No.12 (2012)en_US
dc.identifier.issn19326203en_US
dc.identifier.other2-s2.0-84871669031en_US
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84871669031&origin=inwarden_US
dc.identifier.urihttp://repository.li.mahidol.ac.th/dspace/handle/123456789/13350-
dc.description.abstractDepression of the peripheral blood platelet count during acute infection is a hallmark of dengue. This thrombocytopenia has been attributed, in part, to an insufficient level of platelet production by megakaryocytes that reside in the bone marrow (BM). Interestingly, it was observed that dengue patients experience BM suppression at the onset of fever. However, few studies focus on the interaction between dengue virus (DENV) and megakaryocytes and how this interaction can lead to a reduction in platelets. In the studies reported herein, BM cells from normal healthy rhesus monkeys (RM) and humans were utilized to identify the cell lineage(s) that were capable of supporting virus infection and replication. A number of techniques were employed in efforts to address this issue. These included the use of viral RNA quantification, nonstructural protein and infectivity assays, phenotypic studies utilizing immunohistochemical staining, anti-differentiation DEAB treatment, and electron microscopy. Cumulative results from these studies revealed that cells in the BM were indeed highly permissive for DENV infection, with human BM having higher levels of viral production compared to RM. DENV-like particles were predominantly observed in multi-nucleated cells that expressed CD61+. These data suggest that megakaryocytes are likely the predominant cell type infected by DENV in BM, which provides one explanation for the thrombocytopenia and the dysfunctional platelets characteristic of dengue virus infection. © 2012 Clark et al.en_US
dc.rightsMahidol Universityen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84871669031&origin=inwarden_US
dc.subjectAgricultural and Biological Sciencesen_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.subjectMedicineen_US
dc.titleMultiploid CD61+ Cells Are the Pre-Dominant Cell Lineage Infected during Acute Dengue Virus Infection in Bone Marrowen_US
dc.typeArticleen_US
dc.rights.holderSCOPUSen_US
dc.identifier.doi10.1371/journal.pone.0052902en_US
Appears in Collections:Scopus 2011-2015

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