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dc.contributor.authorAiyada Aroonsrien_US
dc.contributor.authorShigeru Kitanien_US
dc.contributor.authorJunko Hashimotoen_US
dc.contributor.authorIkuko Kosoneen_US
dc.contributor.authorMiho Izumikawaen_US
dc.contributor.authorMamoru Komatsuen_US
dc.contributor.authorNobuyuki Fujitaen_US
dc.contributor.authorYoko Takahashien_US
dc.contributor.authorKazuo Shin-yaen_US
dc.contributor.authorHaruo Ikedaen_US
dc.contributor.authorTakuya Nihiraen_US
dc.contributor.otherOsaka Universityen_US
dc.contributor.otherBiomedicinal Information Research Centeren_US
dc.contributor.otherKitasato Universityen_US
dc.contributor.otherTokyo Institute of Technologyen_US
dc.contributor.otherMahidol Universityen_US
dc.identifier.citationApplied and Environmental Microbiology. Vol.78, No.22 (2012), 8015-8024en_US
dc.description.abstractThe γ-butyrolactone autoregulator signaling cascades have been shown to control secondary metabolism and/or morphological development among many Streptomyces species. However, the conservation and variation of the regulatory systems among actinomycetes remain to be clarified. The genome sequence of Kitasatospora setae, which also belongs to the family Streptomycetaceae containing the genus Streptomyces, has revealed the presence of three homologues of the autoregulator receptor: KsbA, which has previously been confirmed to be involved only in secondary metabolism; KsbB; and KsbC. We describe here the characterization of ksbC, whose regulatory cluster closely resembles the Streptomyces virginiae barA locus responsible for the autoregulator signaling cascade. Deletion of the gene ksbC resulted in lowered production of bafilomycin and a defect of aerial mycelium formation, together with the early and enhanced production of a novel β-carboline alkaloid named kitasetaline. A putative kitasetaline biosynthetic gene cluster was identified, and its expression in a heterologous host led to the production of kitasetaline together with JBIR-133, the production of which is also detected in the ksbC disruptant, and JBIR-134 as novel β-carboline alkaloids, indicating that these genes were biosynthetic genes for β-carboline alkaloid and thus are the first such genes to be discovered in bacteria. © 2012, American Society for Microbiology.en_US
dc.rightsMahidol Universityen_US
dc.subjectAgricultural and Biological Sciencesen_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.subjectEnvironmental Scienceen_US
dc.subjectImmunology and Microbiologyen_US
dc.titlePleiotropic control of secondary metabolism and morphological development by KsbC, a butyrolactone autoregulator receptor homologue in Kitasatospora setaeen_US
Appears in Collections:Scopus 2011-2015

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