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http://repository.li.mahidol.ac.th/dspace/handle/123456789/13546| Title: | Facile synthesis and anticancer activity of C-10 non-acetal deoxoartemisinin dimers |
| Authors: | Supannee Phothongkam Sirirat Chancharunee Angkana Saovapakhiran Uthai Wichai Manat Pohmakotr Chiang Mai University Naresuan University Mahidol University |
| Keywords: | Biochemistry, Genetics and Molecular Biology;Chemistry;Pharmacology, Toxicology and Pharmaceutics |
| Issue Date: | 15-Dec-2012 |
| Citation: | Bioorganic and Medicinal Chemistry Letters. Vol.22, No.24 (2012), 7598-7601 |
| Abstract: | In this research, N-(2-aminoethyl)glycine-linked C-10 non-acetal deoxoartemisinin dimers were synthesized by using solution phase peptide synthesis approach. In addition, chemical modification of the C-10 non-acetal deoxoartemisinin monomers and dimers by adding a lysine unit to the N-terminus has been performed. The biological activities of all synthesized compounds were evaluated against the colon cancer cell line (Caco-2). The non-acetal deoxoartemisinin monomers 12a, 15a-c and dime rs 13a, 16a-c were active against Caco-2 cells and more potent than dihydroartemisinin. © 2012 Elsevier Ltd. All rights reserved. |
| URI: | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84870236110&origin=inward http://repository.li.mahidol.ac.th/dspace/handle/123456789/13546 |
| ISSN: | 14643405 0960894X |
| Appears in Collections: | Scopus 2011-2015 |
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