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Title: Facile synthesis and anticancer activity of C-10 non-acetal deoxoartemisinin dimers
Authors: Supannee Phothongkam
Sirirat Chancharunee
Angkana Saovapakhiran
Uthai Wichai
Manat Pohmakotr
Chiang Mai University
Naresuan University
Mahidol University
Keywords: Biochemistry, Genetics and Molecular Biology;Chemistry;Pharmacology, Toxicology and Pharmaceutics
Issue Date: 15-Dec-2012
Citation: Bioorganic and Medicinal Chemistry Letters. Vol.22, No.24 (2012), 7598-7601
Abstract: In this research, N-(2-aminoethyl)glycine-linked C-10 non-acetal deoxoartemisinin dimers were synthesized by using solution phase peptide synthesis approach. In addition, chemical modification of the C-10 non-acetal deoxoartemisinin monomers and dimers by adding a lysine unit to the N-terminus has been performed. The biological activities of all synthesized compounds were evaluated against the colon cancer cell line (Caco-2). The non-acetal deoxoartemisinin monomers 12a, 15a-c and dime rs 13a, 16a-c were active against Caco-2 cells and more potent than dihydroartemisinin. © 2012 Elsevier Ltd. All rights reserved.
ISSN: 14643405
Appears in Collections:Scopus 2011-2015

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