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dc.contributor.authorSupannee Phothongkamen_US
dc.contributor.authorSirirat Chancharuneeen_US
dc.contributor.authorAngkana Saovapakhiranen_US
dc.contributor.authorUthai Wichaien_US
dc.contributor.authorManat Pohmakotren_US
dc.contributor.otherChiang Mai Universityen_US
dc.contributor.otherNaresuan Universityen_US
dc.contributor.otherMahidol Universityen_US
dc.date.accessioned2018-06-11T04:32:24Z-
dc.date.available2018-06-11T04:32:24Z-
dc.date.issued2012-12-15en_US
dc.identifier.citationBioorganic and Medicinal Chemistry Letters. Vol.22, No.24 (2012), 7598-7601en_US
dc.identifier.issn14643405en_US
dc.identifier.issn0960894Xen_US
dc.identifier.other2-s2.0-84870236110en_US
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84870236110&origin=inwarden_US
dc.identifier.urihttp://repository.li.mahidol.ac.th/dspace/handle/123456789/13546-
dc.description.abstractIn this research, N-(2-aminoethyl)glycine-linked C-10 non-acetal deoxoartemisinin dimers were synthesized by using solution phase peptide synthesis approach. In addition, chemical modification of the C-10 non-acetal deoxoartemisinin monomers and dimers by adding a lysine unit to the N-terminus has been performed. The biological activities of all synthesized compounds were evaluated against the colon cancer cell line (Caco-2). The non-acetal deoxoartemisinin monomers 12a, 15a-c and dime rs 13a, 16a-c were active against Caco-2 cells and more potent than dihydroartemisinin. © 2012 Elsevier Ltd. All rights reserved.en_US
dc.rightsMahidol Universityen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84870236110&origin=inwarden_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.subjectChemistryen_US
dc.subjectPharmacology, Toxicology and Pharmaceuticsen_US
dc.titleFacile synthesis and anticancer activity of C-10 non-acetal deoxoartemisinin dimersen_US
dc.typeArticleen_US
dc.rights.holderSCOPUSen_US
dc.identifier.doi10.1016/j.bmcl.2012.10.020en_US
Appears in Collections:Scopus 2011-2015

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