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Title: Update on the proteomics of major arthropod vectors of human and animal pathogens
Authors: Sirilaksana Patramool
Valérie Choumet
Pornapat Surasombatpattana
Laurence Sabatier
Frédéric Thomas
Supatra Thongrungkiat
Thierry Rabilloud
Nathalie Boulanger
David G. Biron
Dorothée Missé
CNRS Centre National de la Recherche Scientifique
Institut Pasteur, Paris
Institut Pluridisciplinaire Hubert Curien
Mahidol University
CEA Grenoble
Universite de Strasbourg
Keywords: Biochemistry, Genetics and Molecular Biology
Issue Date: 1-Dec-2012
Citation: Proteomics. Vol.12, No.23-24 (2012), 3510-3523
Abstract: Vector-borne diseases (VBDs) are defined as infectious diseases of humans and animals caused by pathogenic agents such as viruses, protists, bacteria, and helminths transmitted by the bite of blood-feeding arthropod (BFA) vectors. VBDs represent a major public health threat in endemic areas, generally subtropical zones, and many are considered to be neglected diseases. Genome sequencing of some arthropod vectors as well as modern proteomic and genomic technologies are expanding our knowledge of arthropod-pathogen interactions. This review describes the proteomic approaches that have been used to investigate diverse biological questions about arthropod vectors, including the interplay between vectors and pathogens. Proteomic studies have identified proteins and biochemical pathways that may be involved in molecular crosstalk in BFA-pathogen associations. Future work can build upon this promising start and functional analyses coupled with interactome bioassays will be carried out to investigate the role of candidate peptides and proteins in BFA-human pathogen associations. Dissection of the host-pathogen interactome will be key to understanding the strategies and biochemical pathways used by BFAs to cope with pathogens. © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
ISSN: 16159861
Appears in Collections:Scopus 2011-2015

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