Simple jQuery Dropdowns
Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/13585
Title: Intracontinental spread of human invasive Salmonella Typhimurium pathovariants in sub-Saharan Africa
Authors: Chinyere K. Okoro
Robert A. Kingsley
Thomas R. Connor
Simon R. Harris
Christopher M. Parry
Manar N. Al-Mashhadani
Samuel Kariuki
Chisomo L. Msefula
Melita A. Gordon
Elizabeth De Pinna
John Wain
Robert S. Heyderman
Stephen Obaro
Pedro L. Alonso
Inacio Mandomando
Calman A. MacLennan
Milagritos D. Tapia
Myron M. Levine
Sharon M. Tennant
Julian Parkhill
Gordon Dougan
Wellcome Trust Sanger Institute
Mahidol University
University of Liverpool
Kenya Medical Research Institute
University of Malawi College of Medicine
University of Malawi
Health Protection Agency
University of East Anglia
University of Bristol
Michigan State University
National Hospital, Abuja
Universitat de Barcelona
Centro de Investigação em Saúde de Manhiça (CISM)
Instituto Nacional de Saude Maputo
Novartis Vaccines Institute for Global Health
University of Birmingham
University of Maryland, Baltimore
Keywords: Biochemistry, Genetics and Molecular Biology
Issue Date: 1-Nov-2012
Citation: Nature Genetics. Vol.44, No.11 (2012), 1215-1221
Abstract: A highly invasive form of non-typhoidal Salmonella (iNTS) disease has recently been documented in many countries in sub-Saharan Africa. The most common Salmonella enterica serovar causing this disease is Typhimurium (Salmonella Typhimurium). We applied whole-genome sequence-based phylogenetic methods to define the population structure of sub-Saharan African invasive Salmonella Typhimurium isolates and compared these to global Salmonella Typhimurium populations. Notably, the vast majority of sub-Saharan invasive Salmonella Typhimurium isolates fell within two closely related, highly clustered phylogenetic lineages that we estimate emerged independently ∼52 and ∼35 years ago in close temporal association with the current HIV pandemic. Clonal replacement of isolates from lineage I by those from lineage II was potentially influenced by the use of chloramphenicol for the treatment of iNTS disease. Our analysis suggests that iNTS disease is in part an epidemic in sub-Saharan Africa caused by highly related Salmonella Typhimurium lineages that may have occupied new niches associated with a compromised human population and antibiotic treatment. © 2012 Nature America, Inc. All rights reserved.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84868201561&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/13585
ISSN: 15461718
10614036
Appears in Collections:Scopus 2011-2015

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.