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Title: A novel tricyclic polyketide and its biosynthetic precursor azaphilone derivatives from the endophytic fungus Dothideomycete sp
Authors: Sarath P D Senadeera
Suthep Wiyakrutta
Chulabhorn Mahidol
Somsak Ruchirawat
Prasat Kittakoop
Chulabhorn Graduate Institute
Mahidol University
Chulabhorn Research Institute
South Carolina Commission on Higher Education
Keywords: Biochemistry, Genetics and Molecular Biology;Chemistry
Issue Date: 21-Sep-2012
Citation: Organic and Biomolecular Chemistry. Vol.10, No.35 (2012), 7220-7226
Abstract: Azaphilone derivatives 1 and 2 and a novel tricyclic polyketide 3, together with a known azaphilone, austdiol (4), were isolated from the endophytic fungus Dothideomycete sp., which was isolated from a Thai medicinal plant, Tiliacora triandra. Compound 3 is the first polyketide having a tricyclic 6,6,6 ring system, which is similar to that of a terpenoid skeleton. The absolute configurations of stereogenic centers in 1-3 were addressed by Mosher's method and biosynthetic analogy with a known azaphilone isolated from the same fungus. Cytotoxic and antimicrobial activities of the isolated compounds were evaluated. © 2012 The Royal Society of Chemistry.
ISSN: 14770520
Appears in Collections:Scopus 2011-2015

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