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Title: Proteomic identification of a direct role for cyclin D1 in DNA damage repair
Authors: Siwanon Jirawatnotai
Yiduo Hu
David M. Livingston
Piotr Sicinski
Harvard Medical School
Mahidol University
Keywords: Biochemistry, Genetics and Molecular Biology;Medicine
Issue Date: 1-Sep-2012
Citation: Cancer Research. Vol.72, No.17 (2012), 4289-4293
Abstract: The human CCND1 gene, which encodes the cell-cycle protein cyclin D1, is one of the most frequently amplified genes in human cancers. Cyclin D1 activates the cyclin-dependent kinases CDK4 and CDK6 and drives cell proliferation. Beyond the cell-cycle role, the full repertoire of cyclin D1 functions in cancer cells is still unclear. Emerging evidence indicates that cyclin D1 may play a role in DNA damage response. In this review, we discuss observations linking cyclin D1 to DNA damage repair and summarize our recent findings, which show a cyclin D1 function in homologous recombination-mediated DNA repair. ©2012 AACR.
ISSN: 15387445
Appears in Collections:Scopus 2011-2015

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