Simple jQuery Dropdowns
Please use this identifier to cite or link to this item:
Title: Variation in human genes encoding adhesion and proinflammatory molecules are associated with severe malaria in the Vietnamese
Authors: S. J. Dunstan
K. A. Rockett
N. T N Quyen
Y. Y. Teo
C. Q. Thai
N. T. Hang
A. Jeffreys
T. G. Clark
K. S. Small
C. P. Simmons
N. Day
S. E. O'Riordan
D. P. Kwiatkowski
J. Farrar
N. H. Phu
T. T. Hien
Oxford University Clinical Research Unit
Nuffield Department of Clinical Medicine
Wellcome Trust Centre for Human Genetics
National University of Singapore
London School of Hygiene & Tropical Medicine
King's College London
Mahidol University
Wellcome Trust Sanger Institute
Keywords: Biochemistry, Genetics and Molecular Biology;Immunology and Microbiology;Medicine
Issue Date: 1-Sep-2012
Citation: Genes and Immunity. Vol.13, No.6 (2012), 503-508
Abstract: The genetic basis for susceptibility to malaria has been studied widely in African populations but less is known of the contribution of specific genetic variants in Asian populations. We genotyped 67 single-nucleotide polymorphisms (SNPs) in 1030 severe malaria cases and 2840 controls from Vietnam. After data quality control, genotyping data of 956 cases and 2350 controls were analysed for 65 SNPs (3 gender confirmation, 62 positioned in/near 42 malarial candidate genes). A total of 14 SNPs were monomorphic and 2 (rs8078340 and rs33950507) were not in Hardy-Weinberg equilibrium in controls (P < 0.01). In all, 7/46 SNPs in 6 genes (ICAM1, IL1A, IL17RC, IL13, LTA and TNF) were associated with severe malaria, with 3/7 SNPs in the TNF/LTA region. Genotype-phenotype correlations between SNPs and clinical parameters revealed that genotypes of rs708567 (IL17RC) correlate with parasitemia (P=0.028, r 2 =0.0086), with GG homozygotes having the lowest parasite burden. Additionally, rs708567 GG homozygotes had a decreased risk of severe malaria (P=0.007, OR=0.78 (95% CI; 0.65-0.93)) and death (P=0.028, OR=0.58 (95% CI; 0.37-0.93)) than those with AA and AG genotypes. In summary, variants in six genes encoding adhesion and proinflammatory molecules are associated with severe malaria in the Vietnamese. Further replicative studies in independent populations will be necessary to confirm these findings. © 2012 Macmillan Publishers Limited. All rights reserved.
ISSN: 14765470
Appears in Collections:Scopus 2011-2015

Files in This Item:
There are no files associated with this item.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.