Please use this identifier to cite or link to this item:
Title: Common variants at 12q15 and 12q24 are associated with infant head circumference
Authors: H. Rob Taal
Beate St Pourcain
Elisabeth Thiering
Shikta Das
Dennis O. Mook-Kanamori
Nicole M. Warrington
Marika Kaakinen
Eskil Kreiner-Møller
Jonathan P. Bradfield
Rachel M. Freathy
Frank Geller
Mònica Guxens
Diana L. Cousminer
Marjan Kerkhof
Nicholas J. Timpson
M. Arfan Ikram
Lawrence J. Beilin
Klaus Bønnelykke
Jessica L. Buxton
Pimphen Charoen
Bo Lund Krogsgaard Chawes
Johan Eriksson
David M. Evans
Albert Hofman
John P. Kemp
Cecilia E. Kim
Norman Klopp
Jari Lahti
Stephen J. Lye
George Mcmahon
Frank D. Mentch
Martina Müller-Nurasyid
Paul F. O'reilly
Inga Prokopenko
Fernando Rivadeneira
Eric A.P. Steegers
Jordi Sunyer
Carla Tiesler
Hanieh Yaghootkar
Myriam Fornage
Albert V. Smith
Sudha Seshadri
Reinhold Schmidt
Stéphanie Debette
Henri A. Vrooman
Sigurdur Sigurdsson
Stefan Ropele
Laura H. Coker
W. T. Longstreth
Wiro J. Niessen
Anita L. Destefano
Alexa Beiser
Alex P. Zijdenbos
Erasmus University Medical Center
University of Bristol
Helmholtz Center Munich German Research Center for Environmental Health
Imperial College London
Weill Cornell Medicine-Qatar
University of Western Australia Faculty of Medicine and Dentistry
University of Toronto
Oulun Yliopisto
Kobenhavns Universitet
The Children's Hospital of Philadelphia
University of Exeter
Statens Serum Institut
Centre de Recerca en Epidemiologia Ambiental, Barcelona
Hospital del Mar
CIBER Epidemiologia Y Salud Publica
Helsingin Yliopisto
University of Groningen, University Medical Center Groningen
Netherlands Consortium for Healthy Ageing (NCHA)
Mahidol University
National Institute for Health and Welfare
Medizinische Hochschule Hannover (MHH)
Ludwig-Maximilians-Universitat Munchen
Klinikum der Universitat Munchen
University of Oxford
Wellcome Trust Centre for Human Genetics
Universitat Pompeu Fabra
German Center for Neurodgenerative Diseases (DZNE)
Boston University School of Medicine
Boston University School of Public Health
University of Texas School of Public Health
Icelandic Research Institute
University of Iceland
National Institute on Aging
University of Mississippi Medical Center
Framingham Heart Study
European Bioinformatics Institute
University of Pennsylvania
Center for Public Health Research (CSISP)
Centre National de Genotypage
Fondation Jean Dausset - CEPH
Ontario Institute for Cancer Research
Broad Institute
Wellcome Trust Sanger Institute
London School of Hygiene & Tropical Medicine
University of California, Davis
Churchill Hospital
Centro de Regulacion Genomica
Health Protection Agency
The University of North Carolina at Chapel Hill
Ita-Suomen yliopisto
Vrije Universiteit Amsterdam
King's College London
National University of Singapore
Universitat Duisburg-Essen
Children's Hospital Boston
Harvard Medical School
University of Southampton
Institut for Sygdomsforebyggelse
University of Copenhagen, Faculty of Health Sciences
University of Edinburgh
University Hospital of Tampere
Tampereen Yliopisto
University of Tartu
Children's Hospital of Iowa
Harokopio University
Mid Sweden University, Ostersund
Turun yliopisto
St George's University of London
Harvard Pilgrim Health Care Institute
Universitat Potsdam
Charité – Universitätsmedizin Berlin
MRC Epidemiology Unit
University of Dundee
Singapore Eye Research Institute
Medizinische Universitat Graz
Wake Forest University School of Medicine
University of Washington, Seattle
Delft University of Technology
Universite de Montreal
Mayo Clinic
Leiden University Medical Center - LUMC
Keywords: Biochemistry, Genetics and Molecular Biology
Issue Date: 1-May-2012
Citation: Nature Genetics. Vol.44, No.5 (2012), 532-538
Abstract: To identify genetic variants associated with head circumference in infancy, we performed a meta-analysis of seven genome-wide association studies (GWAS) (N = 10,768 individuals of European ancestry enrolled in pregnancy and/or birth cohorts) and followed up three lead signals in six replication studies (combined N = 19,089). rs7980687 on chromosome 12q24 (P = 8.1 × 10 -9 ) and rs1042725 on chromosome 12q15 (P = 2.8 × 10 -10 ) were robustly associated with head circumference in infancy. Although these loci have previously been associated with adult height, their effects on infant head circumference were largely independent of height (P = 3.8 × 10 -7 for rs7980687 and P = 1.3 × 10 -7 for rs1042725 after adjustment for infant height). A third signal, rs11655470 on chromosome 17q21, showed suggestive evidence of association with head circumference (P = 3.9 × 10 -6 ). SNPs correlated to the 17q21 signal have shown genome-wide association with adult intracranial volume, Parkinson's disease and other neurodegenerative diseases, indicating that a common genetic variant in this region might link early brain growth with neurological disease in later life. © 2012 Nature America, Inc. All rights reserved.
ISSN: 15461718
Appears in Collections:Scopus 2011-2015

Files in This Item:
There are no files associated with this item.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.