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Title: Antimycobacterial activity of bisbenzylisoquinoline alkaloids from Tiliacora triandra against multidrug-resistant isolates of Mycobacterium tuberculosis
Authors: Sanya Sureram
Sarath P D Senadeera
Poonpilas Hongmanee
Chulabhorn Mahidol
Somsak Ruchirawat
Prasat Kittakoop
Chulabhorn Research Institute
Chulabhorn Graduate Institute
Mahidol University
South Carolina Commission on Higher Education
Keywords: Biochemistry, Genetics and Molecular Biology;Chemistry;Pharmacology, Toxicology and Pharmaceutics
Issue Date: 15-Apr-2012
Citation: Bioorganic and Medicinal Chemistry Letters. Vol.22, No.8 (2012), 2902-2905
Abstract: Bisbenzylisoquinoline alkaloids, tiliacorinine (1), 2′- nortiliacorinine (2), and tiliacorine (3), isolated from the edible plant, Tiliacora triandra, as well as a synthetic derivative, 13′-bromo- tiliacorinine (4), were tested against 59 clinical isolates of multidrug-resistant Mycobacterium tuberculosis (MDR-MTB). The alkaloids 1-4 showed MIC values ranging from 0.7 to 6.2 μg/ml, but they exhibited the MIC value at 3.1 μg/ml against most MDR-MTB isolates. The present work suggests that bisbenzylisoquinoline alkaloids are potential new chemical scaffolds for antimycobacterial activity. © 2012 Elsevier Ltd. All rights reserved.
ISSN: 14643405
Appears in Collections:Scopus 2011-2015

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