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dc.contributor.authorSupaluk Prachayasittikulen_US
dc.contributor.authorApilak Worachartcheewanen_US
dc.contributor.authorRatchanok Pingaewen_US
dc.contributor.authorThummaruk Suksrichavaliten_US
dc.contributor.authorChartchalerm Isarankura-Na-Ayudhyaen_US
dc.contributor.authorSomsak Ruchirawaten_US
dc.contributor.authorVirapong Prachayasittikulen_US
dc.contributor.otherSrinakharinwirot Universityen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherChulabhorn Research Instituteen_US
dc.identifier.citationLetters in Drug Design and Discovery. Vol.9, No.3 (2012), 282-287en_US
dc.description.abstract5-Substituted uracils were reported to be important core structure of diverse therapeutics. Herein, novel mixed ligand transition metal (Mn, Cu, Ni) complexes of 5-iodouracil (5Iu) with 8-hydroxyquinoline or 8HQ (1-3) and 5-nitrouracil (5Nu) with 8HQ (4-6) have been synthesized. The metal complexes 1-6 exert significant cytotoxicity against HepG2, A-549, HuCCA-1 and MOLT-3 cell lines. Particularly, the cytotoxicities of tested complexes against HepG2 cells show their IC 50 values lower than the reference drug. Cu complex of 5Nu (5Nu-Cu-8HQ, 5) is the most potent and promising cytotoxic compound. Mn complex of 5Iu (5Iu-Mn-8HQ, 1) is shown to be the most potent antioxidant. This finding reveals the application of using simple and commercially available bioactive ligands like 5Iu, 5Nu and 8HQ for the design and construction of new lead compounds with significant and promising bioactivities. © 2012 Bentham Science Publishers.en_US
dc.rightsMahidol Universityen_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.subjectPharmacology, Toxicology and Pharmaceuticsen_US
dc.titleMetal complexes of uracil derivatives with cytotoxicity and superoxide scavenging activityen_US
Appears in Collections:Scopus 2011-2015

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