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dc.contributor.authorCatrin E. Mooreen_US
dc.contributor.authorBranwen J. Hennigen_US
dc.contributor.authorKirsten P. Perretten_US
dc.contributor.authorJ. Claire Hoeen_US
dc.contributor.authorSue J. Leeen_US
dc.contributor.authorHelen Fletcheren_US
dc.contributor.authorDenise Brocklebanken_US
dc.contributor.authorDaniel O'Connoren_US
dc.contributor.authorMatthew D. Snapeen_US
dc.contributor.authorAndrew J. Hallen_US
dc.contributor.authorShelley Segalen_US
dc.contributor.authorAdrian V.S. Hillen_US
dc.contributor.authorAndrew J. Pollardaen_US
dc.contributor.otherUniversity of Oxforden_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherLondon School of Hygiene & Tropical Medicineen_US
dc.contributor.otherWellcome Trust Centre for Human Geneticsen_US
dc.contributor.otherUniversity of Melbourneen_US
dc.contributor.otherAngkor Hospital for Childrenen_US
dc.date.accessioned2018-06-11T04:39:01Z-
dc.date.available2018-06-11T04:39:01Z-
dc.date.issued2012-03-01en_US
dc.identifier.citationClinical and Vaccine Immunology. Vol.19, No.3 (2012), 295-303en_US
dc.identifier.issn1556679Xen_US
dc.identifier.issn15566811en_US
dc.identifier.other2-s2.0-84863298293en_US
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84863298293&origin=inwarden_US
dc.identifier.urihttp://repository.li.mahidol.ac.th/dspace/handle/123456789/13795-
dc.description.abstractThe rate of decay of antibody concentration following serogroup C meningococcal (MenC) polysaccharide-protein conjugate vaccination varies between individuals. This depends partly on vaccination age but may be influenced by human genetics. We studied 721 single nucleotide polymorphisms (SNPs) across 131 candidate genes in a first cohort of 905 Caucasians (11 to 21 years old; mean time after vaccination, 4.9 years) and 30 SNPs across 17 genes in a replication study using 155 children, aged 6 to 12 years (mean time after vaccination, 6.7 years), and 196 infants (1 year old; mean time after vaccination, 8 months). Individuals were classified as responders or nonresponders for total MenC IgG concentration and MenC serum bactericidal antibody (SBA) measurements. Associated genes were examined further for quantitative outcome measures. Fifty-nine SNPs in 37 genes were associated with IgG persistence (adjusted for age at measurement), and 56 SNPs in 36 genes were associated with SBA persistence (adjusted for age at measurement and vaccine used). Three SNPs each within the Toll-like receptor 3 (TLR3) (rs3775291, rs3775292, and rs5743312) and CD44 (rs11033013, rs353644, and rs996076) genes were associated with IgG (adjusted for age at measurement) or SBA (adjusted for age at measurement and vaccine used) persistence in the initial genetic study (P, 0.02 to 0.04). Single SNPs within the TLR3 (rs7657186) (P = 0.004 [unadjusted]) and CD44 (rs12419062) (P = 0.01 [unadjusted] ) genes were associated with IgG persistence in the replication study. These results suggest that genetic polymorphisms in the TLR3 and CD44 genes are associated with the persistence of the immune response to MenC vaccines 1 to 6 years after vaccination. Copyright © 2012, American Society for Microbiology. All Rights Reserved.en_US
dc.rightsMahidol Universityen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84863298293&origin=inwarden_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.subjectImmunology and Microbiologyen_US
dc.subjectMedicineen_US
dc.titleSingle nucleotide polymorphisms in the toll-like receptor 3 and CD44 genes are associated with persistence of vaccine-induced immunity to the serogroup C meningococcal conjugate vaccineen_US
dc.typeArticleen_US
dc.rights.holderSCOPUSen_US
dc.identifier.doi10.1128/CVI.05379-11en_US
Appears in Collections:Scopus 2011-2015

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