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Title: Preparation and biocompatibility study of in situ forming polymer implants in rat brains
Authors: Norased Nasongkla
Atthaporn Boongird
Suradej Hongeng
Chawan Manaspon
Noppadol Larbcharoensub
Mahidol University
Keywords: Biochemistry, Genetics and Molecular Biology;Chemical Engineering;Engineering;Materials Science
Issue Date: 1-Feb-2012
Citation: Journal of Materials Science: Materials in Medicine. Vol.23, No.2 (2012), 497-505
Abstract: We describe the development of polymer implants that were designed to solidify once injected into rat brains. These implants comprised of glycofurol and copolymers of D,Llactide (LA), ε-caprolactone and poly(ethylene glycol) (PLECs). Scanning electron microscopy (SEM) and gel permeation chromatography (GPC) showed that the extent of implant degradation was increased with LA content in copolymers. SEM analysis revealed the formation of porosity on implant surface as the degradation proceeds. PLEC with 19.3% mole of LA was chosen to inject in rat brains at the volume of 10, 25 and 40 ll. Body weights, hematological and histopathological data of rats treated with implants were evaluated on day 3, 6, 14, 30 and 45 after the injection. Polymer solution at the injection volume of 10 ll were tolerated relatively well compared to those of 25 and 40 ll as confirmed by higher body weight and healing action (fibrosis tissue) 30 days after treatment. The results from this study suggest a possible application as drug delivery systems that can bypass the blood brain barrier. © 2011 Springer Science+Business Media, LLC.
ISSN: 15734838
Appears in Collections:Scopus 2011-2015

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