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Title: HLA class II restriction of HIV-1 clade-specific neutralizing antibody responses in ethnic Thai recipients of the RV144 prime-boost vaccine combination of ALVAC-HIV and AIDSVAX ® B/E
Authors: Robert Paris
Sasitorn Bejrachandra
Prasert Thongcharoen
Sorachai Nitayaphan
Punnee Pitisuttithum
Anna Sambor
Sanjay Gurunathan
Donald Francis
Silvia Ratto-Kim
Chitraporn Karnasuta
Mark S. de Souza
Victoria R. Polonis
Arthur E. Brown
Jerome H. Kim
Henry A. Stephens
Armed Forces Research Institute of Medical Sciences, Thailand
Faculty of Medicine, Siriraj Hospital, Mahidol University
Mahidol University
United States Military HIV Research Program/Henry M. Jackson Foundation
Sanofi Pasteur
Global Solutions for Infectious Diseases
Walter Reed Army Institute of Research
Keywords: Biochemistry, Genetics and Molecular Biology;Immunology and Microbiology;Medicine;Veterinary
Issue Date: 20-Jan-2012
Citation: Vaccine. Vol.30, No.5 (2012), 832-836
Abstract: Immune responses to vaccines may be influenced or associated with allelic variants of host genes such as those encoding human leucocyte antigens (HLA). We have molecularly determined the HLA class II DR and DQ gene, allele and haploype profiles in HIV-1 negative ethnic Thai recipients of an HIV-1 prime boost vaccine regimen, designed to induce neutralizing antibody (NAb) responses to HIV-1 CRF01_AE. Non-response to vaccine associated with DRB1*11 (3/32 responders vs. 7/13 non-responders, p c =0.027) and DRB1*16:02 (0/32 responders vs. 4/13 non-responders, p c =0.078) alleles. Furthermore, vaccine recipients with HLA-DQ heterodimers encoded by DQA1*05:01 and DQB1*03:01 alleles, were much less likely to produce NAb (p=0.009). These data suggest that the lack of response to a vaccine designed to induce clade-specific NAb to HIV-1 is associated with the presence of certain HLA class II alleles and heterodimers in some Southeast Asians. © 2011.
ISSN: 18732518
Appears in Collections:Scopus 2011-2015

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