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Title: New updating into hemoglobinopathies
Authors: Suthat Fucharoen
P. Winichagoon
Mahidol University
Keywords: Biochemistry, Genetics and Molecular Biology;Medicine
Issue Date: 1-Jan-2012
Citation: International Journal of Laboratory Hematology. Vol.34, No.6 (2012), 559-565
Abstract: Thalassemia and abnormal hemoglobin are the most common genetic disorders and are considered health problems in many developing countries. In the last few years, there has been much progress in laboratory diagnosis, treatment and control of thalassemia. The variation in the clinical severity in both a- and b-thalassemia reflects a genotype-phenotype interaction. This is important for future therapeutic intervention and should be well characterized in each population. The quality of life of the patients is much improved with regular blood transfusion and novel iron chelators. The cure for thalassemia is possible by stem cell transplantation and future gene therapy. It is expected that under multinational collaboration the prevention of thalassemia will happen worldwide. © 2012 Blackwell Publishing Ltd.
ISSN: 1751553X
Appears in Collections:Scopus 2011-2015

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