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dc.contributor.authorPensri Saeleeen_US
dc.contributor.authorUbol Chuensumranen_US
dc.contributor.authorSopit Wongkhamen_US
dc.contributor.authorSunanta Chariyalertsaken_US
dc.contributor.authorDanai Tiwawechen_US
dc.contributor.authorSongsak Petmitren_US
dc.contributor.otherNational Cancer Institute Thailanden_US
dc.contributor.otherSuan Dusit Universityen_US
dc.contributor.otherKhon Kaen Universityen_US
dc.contributor.otherMahidol Universityen_US
dc.identifier.citationAsian Pacific Journal of Cancer Prevention. Vol.13, No.7 (2012), 3489-3493en_US
dc.description.abstractHepatocellular carcinoma (HCC), the most common primary hepatic tumor, is highly prevalent in the Asia-Pacific region, including Thailand. Many genetic and epigenetic alterations in HCC have been elucidated. The aim of this study was to determine whether aberrant methylation of the suppressor of cytokine signaling 1 gene (SOCS1) occurs in HCCs. Methylation specific-PCR assays were performed to identify the methylation status of SOCS1 in 29 tumors and their corresponding normal liver tissues. An abnormal methylation status was detected in 17 (59%), with a higher prevalence of aberrant SOCS1 methylation significantly correlating with HCC treated without chemotherapy (OR=0.04, 95%CI=0.01-0.31; P=0.001). This study suggests that epigenetic aberrant SOCS1 methylation may be a predictive marker for HCC patients.en_US
dc.rightsMahidol Universityen_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.titleHypermethylation of suppressor of cytokine signaling 1 in hepatocellular carcinoma patientsen_US
Appears in Collections:Scopus 2011-2015

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