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Title: Beyond free radical scavenging: Beneficial effects of edaravone (Radicut) in various diseases (Review)
Authors: Kiyoshi Kikuchi
Nobuyuki Takeshige
Naoki Miura
Yoko Morimoto
Takashi Ito
Salunya Tancharoen
Kei Miyata
Chiemi Kikuchi
Narumi Iida
Hisaaki Uchikado
Naohisa Miyagi
Naoto Shiomi
Terukazu Kuramoto
Ikuro Maruyama
Motohiro Morioka
Ko Ichi Kawahara
Yame Public Hospital
Kurume University School of Medicine
Kagoshima University
Kagoshima University Faculty of Medicine
Mahidol University
Nishida Koutoku Hospital
Kohjin Co., Ltd
Saiseikai Shiga Hospital
Omuta City General Hospital
Osaka Institute of Technology
Keywords: Biochemistry, Genetics and Molecular Biology;Immunology and Microbiology
Issue Date: 1-Jan-2012
Citation: Experimental and Therapeutic Medicine. Vol.3, No.1 (2012), 3-8
Abstract: Free radicals play an important role in the pathogenesis of a variety of diseases; thus, they are an attractive target for therapeutic intervention in these diseases. Compounds capable of scavenging free radicals have been developed for this purpose and some, developed for the treatment of cerebral ischemic stroke, have progressed to clinical trials. One such scavenger, edaravone, is used to treat patients within 24 h of stroke. Edaravone, which can diffuse into many disease-affected organs, also shows protective effects in the heart, lung, intestine, liver, pancreas, kidney, bladder and testis. As well as scavenging free radicals, edaravone has anti-apoptotic, anti-necrotic and anti-cytokine effects in various diseases. Here, we critically review the literature on its clinical efficacy and examine whether edaravone should be considered a candidate for worldwide development, focusing on its effects on diseases other than cerebral infarction. Edaravone has been safely used as a free radical scavenger for more than 10 years; we propose that edaravone may offer a novel treatment option for several diseases.
ISSN: 17921015
Appears in Collections:Scopus 2011-2015

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