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Title: | Development of an electronic nose for detection and discrimination of exhaled breath of hepatocellular carcinoma patients |
Authors: | Thara Seesaard Chayanin Khunarak Teerakiat Kerdcharoen Taya Kitiyakara Mahidol University |
Keywords: | Computer Science;Engineering |
Issue Date: | 1-Dec-2012 |
Citation: | Conference Proceedings - IEEE International Conference on Systems, Man and Cybernetics. (2012), 1622-1626 |
Abstract: | An electronic nose (E-nose) has been designed and fabricated for detection of liver cancer based on measurement of the volatiles in the exhaled breath. This e-nose system is in the form of a briefcase, practical for adoption in both clinical and on field uses. The sensing unit is based on eight commercial metal oxide semiconductor gas sensors that are sensitive to a broad range of volatile chemicals, such as ammonia, sulfides, alcohol and hydrocarbons, sufficient to cover the chemical species contained in the human exhaled breath. Delivery of the odor samples to e-nose can be done easily by collecting the exhaled molecules from face mask worn by patients for several minutes. We have demonstrated the preliminary performance of this portable e-nose by comparing the odor of the breath based on two groups of people, patients diagnosed with hepatocellular carcinoma (HCC) and healthy control. It was found that this e-nose can discriminate the patterns of volatile organic compounds (VOCs) from these two groups, as analyzed by the principal component analysis (PCA). With further validation and development, this e-nose may become very useful for monitoring the exhaled as a screening device for detecting patients with early stage liver cancer. Such a device would help reduce the high mortality associated with this disease. © 2012 IEEE. |
URI: | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84872405820&origin=inward http://repository.li.mahidol.ac.th/dspace/handle/123456789/14014 |
ISSN: | 1062922X |
Appears in Collections: | Scopus 2011-2015 |
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