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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/14051
Title: Classification of complete blood count and haemoglobin typing data by a C4.5 decision tree, a naïve Bayes classifier and a multilayer perceptron for thalassaemia screening
Authors: Damrongrit Setsirichok
Theera Piroonratana
Waranyu Wongseree
Touchpong Usavanarong
Nuttawut Paulkhaolarn
Chompunut Kanjanakorn
Monchan Sirikong
Chanin Limwongse
Nachol Chaiyaratana
King Mongkut's University of Technology North Bangkok
Mahidol University
Keywords: Computer Science;Medicine
Issue Date: 1-Mar-2012
Citation: Biomedical Signal Processing and Control. Vol.7, No.2 (2012), 202-212
Abstract: This article presents the classification of blood characteristics by a C4.5 decision tree, a naïve Bayes classifier and a multilayer perceptron for thalassaemia screening. The aim is to classify eighteen classes of thalassaemia abnormality, which have a high prevalence in Thailand, and one control class by inspecting data characterised by a complete blood count (CBC) and haemoglobin typing. Two indices namely a haemoglobin concentration (HB) and a mean corpuscular volume (MCV) are the chosen CBC attributes. On the other hand, known types of haemoglobin from six ranges of retention time identified via high performance liquid chromatography (HPLC) are the chosen haemoglobin typing attributes. The stratified 10-fold cross-validation results indicate that the best classification performance with average accuracy of 93.23% (standard deviation = 1.67%) and 92.60% (standard deviation = 1.75%) is achieved when the naïve Bayes classifier and the multilayer perceptron are respectively applied to samples which have been pre-processed by attribute discretisation. The results also suggest that the HB attribute is redundant. Moreover, the achieved classification performance is significantly higher than that obtained using only haemoglobin typing attributes as classifier inputs. Subsequently, the naïve Bayes classifier and the multilayer perceptron are applied to an additional data set in a clinical trial which respectively results in accuracy of 99.39% and 99.71%. These results suggest that a combination of CBC and haemoglobin typing analysis with a naïve Bayes classifier or a multilayer perceptron is highly suitable for automatic thalassaemia screening. © 2011 Elsevier Ltd. All rights reserved.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84857373261&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/14051
ISSN: 17468108
17468094
Appears in Collections:Scopus 2011-2015

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