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Title: Inhibition of HMGB1 translocation by green tea extract in rats exposed to environmental tobacco smoke
Authors: Sirintip Chaichalotornkul
Wisuda Suvitayavat
Vanida Sangalangkarn
Yuko Nawa
Kiyoshi Kikuchi
Koichi Kawahara
Tawee Saiwichai
Somphong Narkpinit
Pratap Singhasivanon
Ikuro Maruyama
Salunya Tancharoen
Mahidol University
Sapporo Medical University School of Medicine
Yame General Hospital
Kagoshima University
Keywords: Environmental Science;Pharmacology, Toxicology and Pharmaceutics
Issue Date: 1-Jan-2012
Citation: EnvironmentAsia. Vol.5, No.1 (2012), 70-76
Abstract: Environmental tobacco smoke (ETS) exposure is linked to carcinogenic, oxidative and inflammatory cellular reactions. Green tea polyphenol reportedly plays a role in the prevention of inflammation-related diseases. To evaluate the effects of green tea extract (GTE) on cellular location of High Mobility Group Box-1 (HMGB1) protein, we studied the lung tissue in rats exposed to cigarette smoke (CS). Rats were divided into three groups; CS, CSG, and C, which were groups of CS-treated only, CS-treated with GTE dietary supplement, and the control, respectively. Our findings by immunocytochemistry showed that abundant HMGB1 translocated from the nucleus to the cytoplasm in the lung tissues of rats that were exposed to CS, whereas HMGB1 was localized to the nuclei of CSG and C group. For in vitro studies, cotinine stimulated the secretion of HMGB1 in a dose and time dependent manner and the HMGB1 level was suppressed by GTE in murine macrophage cell lines. Our results could suggest that GTE supplementation which could suppress HMGB1 may offer a beneficial effect against diseases.
ISSN: 19061714
Appears in Collections:Scopus 2011-2015

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