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dc.contributor.authorSirintip Chaichalotornkulen_US
dc.contributor.authorWisuda Suvitayavaten_US
dc.contributor.authorVanida Sangalangkarnen_US
dc.contributor.authorYuko Nawaen_US
dc.contributor.authorKiyoshi Kikuchien_US
dc.contributor.authorKoichi Kawaharaen_US
dc.contributor.authorTawee Saiwichaien_US
dc.contributor.authorSomphong Narkpiniten_US
dc.contributor.authorPratap Singhasivanonen_US
dc.contributor.authorIkuro Maruyamaen_US
dc.contributor.authorSalunya Tancharoenen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherSapporo Medical University School of Medicineen_US
dc.contributor.otherYame General Hospitalen_US
dc.contributor.otherKagoshima Universityen_US
dc.identifier.citationEnvironmentAsia. Vol.5, No.1 (2012), 70-76en_US
dc.description.abstractEnvironmental tobacco smoke (ETS) exposure is linked to carcinogenic, oxidative and inflammatory cellular reactions. Green tea polyphenol reportedly plays a role in the prevention of inflammation-related diseases. To evaluate the effects of green tea extract (GTE) on cellular location of High Mobility Group Box-1 (HMGB1) protein, we studied the lung tissue in rats exposed to cigarette smoke (CS). Rats were divided into three groups; CS, CSG, and C, which were groups of CS-treated only, CS-treated with GTE dietary supplement, and the control, respectively. Our findings by immunocytochemistry showed that abundant HMGB1 translocated from the nucleus to the cytoplasm in the lung tissues of rats that were exposed to CS, whereas HMGB1 was localized to the nuclei of CSG and C group. For in vitro studies, cotinine stimulated the secretion of HMGB1 in a dose and time dependent manner and the HMGB1 level was suppressed by GTE in murine macrophage cell lines. Our results could suggest that GTE supplementation which could suppress HMGB1 may offer a beneficial effect against diseases.en_US
dc.rightsMahidol Universityen_US
dc.subjectEnvironmental Scienceen_US
dc.subjectPharmacology, Toxicology and Pharmaceuticsen_US
dc.titleInhibition of HMGB1 translocation by green tea extract in rats exposed to environmental tobacco smokeen_US
Appears in Collections:Scopus 2011-2015

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