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Title: The involvement of microglial cells in japanese encephalitis infections
Authors: Thananya Thongtan
Chutima Thepparit
Duncan R. Smith
Chulalongkorn University
Mahidol University
Keywords: Immunology and Microbiology;Medicine
Issue Date: 18-Sep-2012
Citation: Clinical and Developmental Immunology. Vol.2012, (2012)
Abstract: Despite the availability of effective vaccines, Japanese encephalitis virus (JEV) infections remain a leading cause of encephalitis in many Asian countries. The virus is transmitted to humans by Culex mosquitoes, and, while the majority of human infections are asymptomatic, up to 30 of JE cases admitted to hospital die and 50 of the survivors suffer from neurological sequelae. Microglia are brain-resident macrophages that play key roles in both the innate and adaptive immune responses in the CNS and are thus of importance in determining the pathology of encephalitis as a result of JEV infection. © 2012 Thananya Thongtan et al.
ISSN: 17402530
Appears in Collections:Scopus 2011-2015

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