Simple jQuery Dropdowns
Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/14275
Title: Pv12, a 6-Cys antigen of Plasmodium vivax, is localized to the merozoite rhoptry
Authors: Jian Li
Daisuke Ito
Jun Hu Chen
Feng Lu
Yang Cheng
Bo Wang
Kwon Soo Ha
Jun Cao
Motomi Torii
Jetsumon Sattabongkot
Takafumi Tsuboi
Eun Taek Han
Kangwon National University
Jiangsu Institute of Parasitic Diseases
Ehime University
Zhejiang Academy of Medical Sciences
Mahidol University
Keywords: Immunology and Microbiology;Medicine
Issue Date: 1-Sep-2012
Citation: Parasitology International. Vol.61, No.3 (2012), 443-449
Abstract: Pf12 in Plasmodium falciparum has been characterized as a merozoite surface protein and the Pf12 gene is actively transcribed during schizont stage. An orthologous gene, Pv12, has been identified in genome of P. vivax, but the protein product has not been characterized. The Pv12 is a 362 amino acid long polypeptide encoded by a single exon gene PVX_113775, for which orthologous genes have been identified in other Plasmodium species by bioinformatic approaches. Pv12 contains two predicted six-cysteine (6-Cys) domains, which may be constrained by predicted disulfide bonds, and a transmembrane domain and a predicted GPI anchor attachment site in C-terminal region. The recombinant Pv12 protein is recognized by serum antibodies of patients naturally exposed to P. vivax and the native Pv12 protein from parasite extract is also recognized by immune mouse serum. The Pv12 is localized in rhoptry; an apical organelle of the merozoite, and the localization pattern of Pv12 is distinct from that of Pf12 in P. falciparum. The present study suggests that Pv12 is immunogenic in humans during parasite infection and it could play an important role in erythrocyte invasion. © 2012 .
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84862778079&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/14275
ISSN: 18730329
13835769
Appears in Collections:Scopus 2011-2015

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.