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Title: Artemisinin-resistant malaria: Research challenges, opportunities, and public health implications
Authors: Rick M. Fairhurst
Gaurvika M.L. Nayyar
Joel G. Breman
Rachel Hallett
Jonathan L. Vennerstrom
Socheat Duong
Pascal Ringwald
Thomas E. Wellems
Christopher V. Plowe
Arjen M. Dondorp
National Institute of Allergy and Infectious Diseases
National Institutes of Health, Bethesda
London School of Hygiene & Tropical Medicine
University of Nebraska Medical Center
Ministry of Health Cambodia
Organisation Mondiale de la Sante
University of Maryland School of Medicine
Mahidol University
Keywords: Immunology and Microbiology;Medicine
Issue Date: 1-Aug-2012
Citation: American Journal of Tropical Medicine and Hygiene. Vol.87, No.2 (2012), 231-241
Abstract: Artemisinin-based combination therapies are the most effective drugs to treat Plasmodium falciparum malaria. Reduced sensitivity to artemisinin monotherapy, coupled with the emergence of parasite resistance to all partner drugs, threaten to place millions of patients at risk of inadequate treatment of malaria. Recognizing the significance and immediacy of this possibility, the Fogarty International Center and the National Institute of Allergy and Infectious Diseases of the U.S. National Institutes of Health convened a conference in November 2010 to bring together the diverse array of stakeholders responding to the growing threat of artemisinin resistance, including scientists from malarious countries in peril. This conference encouraged and enabled experts to share their recent unpublished data from studies that may improve our understanding of artemisinin resistance. Conference sessions addressed research priorities to forestall artemisinin resistance and fostered collaborations between field- and laboratory-based researchers and international programs, with the aim of translating new scientific evidence into public health solutions. Inspired by this conference, this review summarizes novel findings and perspectives on artemisinin resistance, approaches for translating research data into relevant public health information, and opportunities for interdisciplinary collaboration to combat artemisinin resistance. Copyright © 2012 by The American Society of Tropical Medicine and Hygiene.
ISSN: 00029637
Appears in Collections:Scopus 2011-2015

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