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Title: A prospective assessment of the accuracy of commercial IgM ELISAs in diagnosis of Japanese encephalitis virus infections in patients with suspected central nervous system infections in Laos
Authors: Catrin E. Moore
Stuart D. Blacksell
Thaksinaporn Taojaikong
Richard G. Jarman
Robert V. Gibbons
Sue J. Lee
Vilada Chansamouth
Soulignasack Thongpaseuth
Mayfong Mayxay
Paul N. Newton
Mahosot Hospital
Mahidol University
Armed Forces Research Institute of Medical Sciences, Thailand
Keywords: Immunology and Microbiology;Medicine
Issue Date: 1-Jul-2012
Citation: American Journal of Tropical Medicine and Hygiene. Vol.87, No.1 (2012), 171-178
Abstract: Japanese encephalitis virus (JEV) is a major cause of encephalitis in Asia. We estimated the diagnostic accuracy of two anti-JEV immunoglobulin M (IgM) enzyme-linked immunosorbent assays (ELISAs) (Panbio and XCyton JEVCheX) compared with a reference standard (AFRIMS JEV MAC ELISA) in a prospective study of the causes of central nervous system infections in Laos. Cerebrospinal fluid (CSF; 515 patients) and serum samples (182 patients) from those admitted to Mahosot Hospital, Vientiane, were tested. The CSF from 14.5% of acute encephalitis syndrome (AES) patients and 10.1% from those with AES and meningitis were positive for anti-JEV IgM in the reference ELISA. The sensitivities for CSF were 65.4%(95%confidence interval [CI] = 51-78) (Xcyton), 69.2% (95%CI = 55-81) (Panb io), however 96.2% (95% CI = 87-100) with Panbio Ravi criteria. Specificities were 89-100%. For admission sera from AES patients, sensitivities and specificities of the Panbio ELISA were 85.7% (95% CI = 42-100%) and 92.9% (95% CI = 83-98%), respectively. Copyright © 2012 by The American Society of Tropical Medicine and Hygiene.
ISSN: 00029637
Appears in Collections:Scopus 2011-2015

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