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dc.contributor.authorNicholas M. Douglasen_US
dc.contributor.authorNicholas M. Ansteyen_US
dc.contributor.authorPierre A. Buffeten_US
dc.contributor.authorJeanne R. Poespoprodjoen_US
dc.contributor.authorTsin W. Yeoen_US
dc.contributor.authorNicholas J. Whiteen_US
dc.contributor.authorRic N. Priceen_US
dc.contributor.otherMenzies School of Health Researchen_US
dc.contributor.otherNuffield Department of Clinical Medicineen_US
dc.contributor.otherRoyal Darwin Hospitalen_US
dc.contributor.otherUniversite Pierre et Marie Curieen_US
dc.contributor.otherHopital Pitie Salpetriereen_US
dc.contributor.otherInstitut Pasteur, Parisen_US
dc.contributor.otherMimika District Health Authorityen_US
dc.contributor.otherPapuan Health and Community Development Foundationen_US
dc.contributor.otherMahidol Universityen_US
dc.identifier.citationMalaria Journal. Vol.11, (2012)en_US
dc.description.abstractPlasmodium vivax threatens nearly half the worlds population and is a significant impediment to achievement of the millennium development goals. It is an important, but incompletely understood, cause of anaemia. This review synthesizes current evidence on the epidemiology, pathogenesis, treatment and consequences of vivax-associated anaemia. Young children are at high risk of clinically significant and potentially severe vivax-associated anaemia, particularly in countries where transmission is intense and relapses are frequent. Despite reaching lower densities than Plasmodium falciparum, Plasmodium vivax causes similar absolute reduction in red blood cell mass because it results in proportionately greater removal of uninfected red blood cells. Severe vivax anaemia is associated with substantial indirect mortality and morbidity through impaired resilience to co-morbidities, obstetric complications and requirement for blood transfusion. Anaemia can be averted by early and effective anti-malarial treatment. © 2012 Douglas et al.; licensee BioMed Central Ltd.en_US
dc.rightsMahidol Universityen_US
dc.subjectImmunology and Microbiologyen_US
dc.titleThe anaemia of Plasmodium vivax malariaen_US
Appears in Collections:Scopus 2011-2015

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