Please use this identifier to cite or link to this item:
Title: Rapid and massive virus-specific plasmablast responses during acute: Dengue virus infection in humans
Authors: Jens Wrammert
Nattawat Onlamoon
Rama S. Akondy
Guey C. Perng
Korakot Polsrila
Anmol Chandele
Marcin Kwissa
Bali Pulendran
Patrick C. Wilson
Orasri Wittawatmongkol
Sutee Yoksan
Nasikarn Angkasekwinai
Kovit Pattanapanyasat
Kulkanya Chokephaibulkit
Rafi Ahmed
Emory University
Mahidol University
University of Chicago
Faculty of Medicine, Thammasat University
Keywords: Immunology and Microbiology
Issue Date: 1-Mar-2012
Citation: Journal of Virology. Vol.86, No.6 (2012), 2911-2918
Abstract: Humoral immune responses are thought to play a major role in dengue virus-induced immunopathology; however, little is known about the plasmablasts producing these antibodies during an ongoing infection. Herein we present an analysis of plasmablast responses in patients with acute dengue virus infection. We found very potent plasmablast responses that often increased more than 1,000-fold over the baseline levels in healthy volunteers. In many patients, these responses made up as much 30% of the peripheral lymphocyte population. These responses were largely dengue virus specific and almost entirely made up of IgG-secreting cells, and plasmablasts reached very high numbers at a time after fever onset that generally coincided with the window where the most serious dengue virus-induced pathology is observed. The presence of these large, rapid, and virus-specific plasmablast responses raises the question as to whether these cells might have a role in dengue immunopathology during the ongoing infection. These findings clearly illustrate the need for a detailed understanding of the repertoire and specificity of the antibodies that these plasmablasts produce. © 2012, American Society for Microbiology.
ISSN: 10985514
Appears in Collections:Scopus 2011-2015

Files in This Item:
There are no files associated with this item.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.