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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/14356
Title: No evidence for spread of Plasmodium falciparum artemisinin resistance to Savannakhet Province, Southern Laos
Authors: Mayfong Mayxay
Maniphone Khanthavong
Odai Chanthongthip
Mallika Imwong
Sue J. Lee
Kasia Stepniewska
Bongkot Soonthornsata
Tiengkham Pongvongsa
Samlane Phompida
Bouasy Hongvanthong
Pascal Ringwald
Nicholas J. White
Paul N. Newton
Wellcome Trust-Mahosot Hospital-Oxford University Tropical Medicine Research Collaboration
University of Health Sciences
Nuffield Department of Clinical Medicine
Parasitology and Entomology
Mahidol University
Savannakhet Provincial Malaria Station
Organisation Mondiale de la Sante
Keywords: Immunology and Microbiology;Medicine
Issue Date: 1-Mar-2012
Citation: American Journal of Tropical Medicine and Hygiene. Vol.86, No.3 (2012), 403-408
Abstract: We conducted an open-label, randomized clinical trial to assess parasite clearance times (PCT) and the efficacy of 4 mg/kg (group 1, n = 22) and 2 mg/kg (group 2, n = 22) of oral artesunate for three days followed by artemetherlumefantrine in patients with uncomplicated Plasmodium falciparum malaria at Xepon Interdistrict Hospital, Savannakhet Province in southern Laos. Slides were read in duplicate. The overall mean (95% confidence interval; range) PCT in hours was 23.2 (21.2-25.3; 12-46) and 22.4 (20.3-24.5; 12-46) for the first and second microscopists, respectively (P = 0.57). Ten (23%) patients remained parasitemic on day 1 after treatment (4 [18%] in group 1 and 6 [27%] in group 2; P = 0.47). No patient had patent asexual parasitemia on the second and third days of treatment. The 42-day polymerase chain reaction-corrected cure rates were 100% in both treatment groups. Serious adverse events did not develop during or after treatment in any patients. In conclusion, no evidence of P. falciparum in vivo resistance to artesunate was found in southern Laos. Copyright © 2012 by The American Society of Tropical Medicine and Hygiene.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84859491275&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/14356
ISSN: 00029637
Appears in Collections:Scopus 2011-2015

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