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Title: Impact of mosquito bites on asexual parasite density and gametocyte prevalence in asymptomatic chronic plasmodium falciparum infections and correlation with IgE and IgG titers
Authors: Ramatoulaye Lawaly
Lassana Konate
Laurence Marrama
Ibrahima Dia
Diawo Diallo
Fatoumata Diène Sarr
Bradley S. Schneider
Isabelle Casademont
Mawlouth Diallo
Paul T. Brey
Anavaj Sakuntabhai
Salah Mecheri
Richard Paul
Institut Pasteur de Dakar
Universite Cheikh Anta Diop
Institut Pasteur, Paris
Institut Pasteur du Laos
Mahidol University
Keywords: Immunology and Microbiology;Medicine
Issue Date: 1-Jan-2012
Citation: Infection and Immunity. Vol.80, No.6 (2012), 2240-2246
Abstract: An immunomodulatory role of arthropod saliva has been well documented, but evidence for an effect on Plasmodium sp. infectiousness remains controversial. Mosquito saliva may orient the immune response toward a Th2 profile, thereby priming a Th2 response against subsequent antigens, including Plasmodium. Orientation toward a Th1 versus a Th2 profile promotes IgG and IgE proliferation, respectively, where the former is crucial for the development of an efficient antiparasite immune response. Here we assessed the direct effect of mosquito bites on the density of Plasmodium falciparum asexual parasites and the prevalence of gametocytes in chronic, asymptomatic infections in a longitudinal cohort study of seasonal transmission. We additionally correlated these parasitological measures with IgE and IgG antiparasite and anti-salivary gland extract titers. The mosquito biting density was positively correlated with the asexual parasite density but not asexual parasite prevalence and was negatively correlated with gametocyte prevalence. Individual anti-salivary gland IgE titers were also negatively correlated with gametocyte carriage and were strongly positively correlated with antiparasite IgE titers, consistent with the hypothesis that mosquito bites predispose individuals to develop an IgE antiparasite response. We provide evidence that mosquito bites have an impact on asymptomatic infections and differentially so for the production of asexual and sexual parasites. An increased research focus on the immunological impact of mosquito bites during asymptomatic infections is warranted, to establish whether strategies targeting the immune response to saliva can reduce the duration of infection and the onward transmission of the parasite. © 2012, American Society for Microbiology.
ISSN: 10985522
Appears in Collections:Scopus 2011-2015

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