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dc.contributor.authorRamatoulaye Lawalyen_US
dc.contributor.authorLassana Konateen_US
dc.contributor.authorLaurence Marramaen_US
dc.contributor.authorIbrahima Diaen_US
dc.contributor.authorDiawo Dialloen_US
dc.contributor.authorFatoumata Diène Sarren_US
dc.contributor.authorBradley S. Schneideren_US
dc.contributor.authorIsabelle Casademonten_US
dc.contributor.authorMawlouth Dialloen_US
dc.contributor.authorPaul T. Breyen_US
dc.contributor.authorAnavaj Sakuntabhaien_US
dc.contributor.authorSalah Mecherien_US
dc.contributor.authorRichard Paulen_US
dc.contributor.otherInstitut Pasteur de Dakaren_US
dc.contributor.otherUniversite Cheikh Anta Diopen_US
dc.contributor.otherInstitut Pasteur, Parisen_US
dc.contributor.otherInstitut Pasteur du Laosen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherGLOBAL VIRAL FORECASTING, INC.en_US
dc.identifier.citationInfection and Immunity. Vol.80, No.6 (2012), 2240-2246en_US
dc.description.abstractAn immunomodulatory role of arthropod saliva has been well documented, but evidence for an effect on Plasmodium sp. infectiousness remains controversial. Mosquito saliva may orient the immune response toward a Th2 profile, thereby priming a Th2 response against subsequent antigens, including Plasmodium. Orientation toward a Th1 versus a Th2 profile promotes IgG and IgE proliferation, respectively, where the former is crucial for the development of an efficient antiparasite immune response. Here we assessed the direct effect of mosquito bites on the density of Plasmodium falciparum asexual parasites and the prevalence of gametocytes in chronic, asymptomatic infections in a longitudinal cohort study of seasonal transmission. We additionally correlated these parasitological measures with IgE and IgG antiparasite and anti-salivary gland extract titers. The mosquito biting density was positively correlated with the asexual parasite density but not asexual parasite prevalence and was negatively correlated with gametocyte prevalence. Individual anti-salivary gland IgE titers were also negatively correlated with gametocyte carriage and were strongly positively correlated with antiparasite IgE titers, consistent with the hypothesis that mosquito bites predispose individuals to develop an IgE antiparasite response. We provide evidence that mosquito bites have an impact on asymptomatic infections and differentially so for the production of asexual and sexual parasites. An increased research focus on the immunological impact of mosquito bites during asymptomatic infections is warranted, to establish whether strategies targeting the immune response to saliva can reduce the duration of infection and the onward transmission of the parasite. © 2012, American Society for Microbiology.en_US
dc.rightsMahidol Universityen_US
dc.subjectImmunology and Microbiologyen_US
dc.titleImpact of mosquito bites on asexual parasite density and gametocyte prevalence in asymptomatic chronic plasmodium falciparum infections and correlation with IgE and IgG titersen_US
Appears in Collections:Scopus 2011-2015

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