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dc.contributor.authorKulkanya Chokephaibulkiten_US
dc.contributor.authorWasana Prasitsuebsaien_US
dc.contributor.authorOrasri Wittawatmongkolen_US
dc.contributor.authorMeena Gorowaraen_US
dc.contributor.authorWanatpreeya Phongsamarten_US
dc.contributor.authorJiratchiya Sophonphanen_US
dc.contributor.authorStephen J. Kerren_US
dc.contributor.authorNirun Vanpraparen_US
dc.contributor.authorThanyawee Puthanakiten_US
dc.contributor.authorChayapa Pasomsapen_US
dc.contributor.authorTulathip Suwanlerken_US
dc.contributor.authorVanitha Sekaren_US
dc.contributor.authorDavid Burgeren_US
dc.contributor.authorJintanat Ananworanichen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherThe HIV Netherlands Australia Thailand Research Collaborationen_US
dc.contributor.otherUniversity of New South Wales (UNSW) Australiaen_US
dc.contributor.otherChulalongkorn Universityen_US
dc.contributor.otherTibotec Inc.en_US
dc.contributor.otherRadboud University Nijmegen Medical Centreen_US
dc.identifier.citationAntiviral Therapy. Vol.17, No.7 (2012), 1263-1269en_US
dc.description.abstractBackground: The Asian population, in general, has higher antiretroviral concentrations than those who are not Asian, but there are limited pharmacokinetic data for darunavir/ritonavir in Asian children. Methods: Thai children aged ≥7 years and with body weight (BW)≥20 kg who were on darunavir/ritonavir for ≥2 weeks underwent 12-h pharmacokinetics with blood sampling before and at 1, 2, 4, 6, 8, 10 and 12 h postdosing. Darunavir/ritonavir doses were 375/100 mg twice daily (BW 20 to < 30 kg, n=12), 450/100 mg twice daily (BW 30 to < 40 kg, n=2) or 600/100 mg twice daily (BW ≥40 kg, n=5). Ritonavir 100 mg soft gel capsules were used instead of solution. Results: Of the 19 children, 8 were female, median age was 13 years (range 7-16) and median BW was 29.4 kg. The median duration of darunavir/ritonavir treatment was 11 months. The geometric mean values for darunavir were 60.3 hxmg/l for the area under the concentration-time curve at 0-12 h (AUC 0-12 ), 8.3 mg/l for the maximum concentration (C max ) and 3.1 for the concentration prior to the next dose (C 12 ) with no differences between dosing groups. All had C 12 above the protein binding adjusted 50% effective concentration (EC 50 ) of protease inhibitor-resistant virus (0.55 mg/l). The darunavir pharmacokinetic parameters were similar to those in non-Asian individuals from the DELPHI study, in which 13 of 20 with BW < 40 kg used 50 or 60 mg ritonavir boosting. Conclusions: Thai children aged ≥7 years who were on standard darunavir dosing with 100 mg ritonavir boosting had adequate and comparable darunavir AUC 0-12 , C max and C 12 to non-Asian children who mainly used lower doses of ritonavir boosting. A ritonavir boosting dose of 100 mg can be used for children weighing ≥20 kg, particularly when lower dose formulations are unavailable or if intolerant to the solution. ©2012 International Medical Press.en_US
dc.rightsMahidol Universityen_US
dc.subjectPharmacology, Toxicology and Pharmaceuticsen_US
dc.titlePharmacokinetics of darunavir/ritonavir in Asian HIV-1-infected children aged ≥7 yearsen_US
Appears in Collections:Scopus 2011-2015

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