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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/14466
Title: MRI study of intracranial hydrodynamics and ventriculoperitoneal shunt responsiveness in patient with normal pressure hydrocephalus
Authors: Theerapol Witthiwej
Pathomlirk Sathira-ankul
Orasa Chawalparit
Wattanachai Chotinaiwattarakul
Nanthasak Tisavipat
Panida Charnchaowanish
Mahidol University
Bangkok Hospital Medical Center
Keywords: Medicine
Issue Date: 1-Dec-2012
Citation: Journal of the Medical Association of Thailand. Vol.95, No.12 (2012), 1556-1562
Abstract: Objective: To determine the predictor for shunt responsive cases in patient with normal pressure hydrocephalus (NPH) by means of magnetic resonance imaging (MRI) cerebrospinal fluid (CSF) flow study at Siriraj hospital. Material and Method: The retrospective study was performed in patients suspected NPH and underwent MRI CSF flow measurement. 2D-phase contrast technique (Achieva, 3 Tesla Philips system) was used as CSF flow analysis. The preoperative and postoperative clinical outcomes were collected and analyzed to determine predictive value of MRI CSF flow measurement in shunt responsive patients. Results: Between 2006 and 2011, twenty NPH patients underwent MRI CSF flow study and were treated by ventriculoperitoneal shunt placement. Fourteen of 20 cases had improved, at least in gait score. Of these, 10 were defined as significant responsive group for overall improvement of outcome (sum of iNPHGS ≥ 3). The mean velocity of the CSF flow through the aqueduct of Sylvius was significant difference between shunt-responsive and non-responsive groups (p < 0.05). The peak velocity was a significant difference between gait responsive and non-responsive groups (p < 0.05). Using a mean velocity threshold 26 mm/sec to identify the significant responsive group, the sensitivity is 50%, specificity 83.3%, positive predictive value 87.5%, and accuracy 70%. In order to identify the gait responsive group by using a threshold of peak velocity 70 mm/sec, the sensitivity was 60%, specificity 83.3%, positive predictive value 81.5%, and accuracy 60%. Conclusion: Using available commercial software in the authors' institute, the mean velocity as well as the peak velocity was a specific value that predicted significant shunt responsiveness in NPH patients.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84871709770&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/14466
ISSN: 01252208
Appears in Collections:Scopus 2011-2015

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