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dc.contributor.authorFatai A. Fehintolaen_US
dc.contributor.authorKimberly K. Scarsien_US
dc.contributor.authorQing Maen_US
dc.contributor.authorSunil Parikhen_US
dc.contributor.authorGene D. Morseen_US
dc.contributor.authorBabafemi Taiwoen_US
dc.contributor.authorIbrahim Tope Akinolaen_US
dc.contributor.authorIsaac F. Adewoleen_US
dc.contributor.authorNiklas Lindegardhen_US
dc.contributor.authorAphiradee Phakderajen_US
dc.contributor.authorOladosu Ojengbedeen_US
dc.contributor.authorRobert L. Murphyen_US
dc.contributor.authorOlusegun O. Akinyinkaen_US
dc.contributor.authorFrancesca T. Aweekaen_US
dc.contributor.otherUniversity of Ibadanen_US
dc.contributor.otherNorthwestern University Feinberg School of Medicineen_US
dc.contributor.otherUniversity at Buffalo, State University of New Yorken_US
dc.contributor.otherUniversity of California, San Franciscoen_US
dc.contributor.otherUniversity College Hospital, Ibadanen_US
dc.contributor.otherMahidol Universityen_US
dc.identifier.citationAIDS Research and Treatment. Vol.2012, (2012)en_US
dc.description.abstractBackground. Nevirapine- (NVP-) based antiretroviral therapy (ART) and artesunate-amodiaquine are frequently coprescribed in areas of HIV and malaria endemicity. We explored the impact of this practice on artesunate and dihydroartemisinin pharmacokinetics. Methods. We conducted a parallel-group pharmacokinetic comparison between HIV-infected patients receiving NVP-based ART (n=10) and ART-naive controls (n=11). Artesunate-amodiaquine 200/600 mg was given daily for three days. Measurement of drug concentrations occurred between 0 and 96 hours after the final dose. Pharmacokinetic parameters were determined using noncompartmental analysis. Results. Comparing the NVP group to controls, clearance of artesunate was reduced 50% (1950 versus 2995 L/h; P=0.03), resulting in a 45% increase in the AUC(105 versus 69 ug hr/L; P=0.02). The half-life of dihydroartemisinin was shorter in the NVP group (1.6 versuss 3.2 h; P=0.004), but other dihydroartemisinin pharmacokinetic parameters were unchanged. A lower conversion of artesunate to dihydroartemisinin was observed in the NVP group (dihydroartemisinin: artesunate AUC=5.6 versuss 8.5 in NVP and control groups, respectively, P=0.008). Conclusion. Although NVP-containing ART impacted some pharmacokinetic parameters of artesunate and dihydroartemisinin, overall exposure was similar or better in the NVP group. © 2012 Fatai A. Fehintola et al.en_US
dc.rightsMahidol Universityen_US
dc.titleNevirapine-based antiretroviral therapy impacts artesunate and dihydroartemisinin disposition in HIV-infected Nigerian adultsen_US
Appears in Collections:Scopus 2011-2015

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