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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/14487
Title: The status of pharmacometrics in pregnancy: Highlights from the 3rd American conference on pharmacometrics
Authors: J. G Coen van Hasselt
Marilee A. Andrew
Mary F. Hebert
Joel Tarning
Paolo Vicini
Donald R. Mattison
The Netherlands Cancer Institute
Amgen - Seattle Office
University of Washington, Seattle
Mahidol University
Pfizer Inc.
National Institute of Child Health and Human Development
Risk Sciences International, Ottawa
Keywords: Medicine;Pharmacology, Toxicology and Pharmaceutics
Issue Date: 1-Dec-2012
Citation: British Journal of Clinical Pharmacology. Vol.74, No.6 (2012), 932-939
Abstract: Physiological changes during pregnancy may alter drug pharmacokinetics. Therefore, mechanistic understanding of these changes and, ultimately, clinical studies in pregnant women are necessary to determine if and how dosing regimens should be adjusted. Because of the typically limited number of patients who can be recruited in this patient group, efficient design and analysis of these studies is of special relevance. This paper is a summary of a conference session organized at the American Conference of Pharmacometrics in April 2011, around the topic of applying pharmacometric methodology to this important problem. The discussion included both design and analysis of clinical studies during pregnancy and in silico predictions. An overview of different pharmacometric methods relevant to this subject was given. The impact of pharmacometrics was illustrated using a range of case examples of studies around pregnancy. © 2012 The Authors. British Journal of Clinical Pharmacology © 2012 The British Pharmacological Society.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84869058991&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/14487
ISSN: 13652125
03065251
Appears in Collections:Scopus 2011-2015

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