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Title: Loss to followup in HIV-infected patients from Asia-pacific region: Results from TAHOD
Authors: Jialun Zhou
Junko Tanuma
Romanee Chaiwarith
Christopher K.C. Lee
Matthew G. Law
Nagalingeswaran Kumarasamy
Praphan Phanuphak
Yi Ming A. Chen
Sasisopin Kiertiburanakul
Fujie Zhang
Saphonn Vonthanak
Rossana Ditangco
Sanjay Pujari
Jun Yong Choi
Tuti Parwati Merati
Evy Yunihastuti
Patrick C.K. Li
Adeeba Kamarulzaman
Van Kinh Nguyen
Thi Thanh Thuy Pham
Poh Lian Lim
University of New South Wales (UNSW) Australia
National Center for Global Health and Medicine
Research Institute for Health Sciences
Hospital Sungai Buloh
YR Gaitonde Centre for AIDS Research and Education
The HIV Netherlands Australia Thailand Research Collaboration
National Yang-Ming University Taiwan
Mahidol University
Capital Medical University China
National Center for HIV/AIDS
Institute of Infectious Diseases
Yonsei University College of Medicine
Universitas Udayana
University of Indonesia, RSUPN Dr. Cipto Mangunkusumo
Queen Elizabeth Hospital Hong Kong
University of Malaya Medical Centre
National Hospital for Tropical Diseases
Bach Mai Hospital
Tan Tock Seng Hospital
Keywords: Medicine
Issue Date: 1-Dec-2012
Citation: AIDS Research and Treatment. Vol.2012, (2012)
Abstract: This study examined characteristics of HIV-infected patients in the TREAT Asia HIV Observational Database who were lost to follow-up (LTFU) from treatment and care. Time from last clinic visit to 31 March 2009 was analysed to determine the interval that best classified LTFU. Patients defined as LTFU were then categorised into permanently LTFU (never returned) and temporary LTFU (re-entered later), and these groups compared. A total of 3626 patients were included (71% male). No clinic visits for 180 days was the best-performing LTFU definition (sensitivity 90.6%, specificity 92.3%). During 7697 person-years of follow-up, 1648 episodes of LFTU were recorded (21.4 per 100-person-years). Patients LFTU were younger (P = 0.002), had HIV viral load ≥500 copies/mL or missing (P = 0.021), had shorter history of HIV infection (P = 0.048), and received no, single- or double-antiretroviral therapy, or a triple-drug regimen containing a protease inhibitor (P < 0.001). 48% of patients LTFU never returned. These patients were more likely to have low or missing haemoglobin (P < 0.001), missing recent HIV viral load (P < 0.001), negative hepatitis C test (P = 0.025), and previous temporary LTFU episodes (P < 0.001). Our analyses suggest that patients not seen at a clinic for 180 days are at high risk of permanent LTFU, and should be aggressively traced. © 2012 Jialun Zhou et al.
ISSN: 20901259
Appears in Collections:Scopus 2011-2015

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